Evidence map›Paper›PMID 32252830›Full record

ArticleHereditas2020

Characterization and functional analysis of SIAH1 during skin and hair follicle development in the angora rabbit (Oryctolagus cuniculus).

Tong Zhou, Yang Chen, Bohao Zhao, Shuaishuai Hu, Jiali Li, Ming Liu, Shuang Liang, Zhiyuan Bao, Xinsheng Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hereditas, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tong ZhouCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Yang ChenCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Bohao ZhaoCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Shuaishuai HuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Jiali LiCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Ming LiuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Shuang LiangCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Zhiyuan BaoCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China.
Xinsheng WuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, China. xswu@yzu.edu.cn.
Yangzhou University · CN

Funding

Modern Agricultural Industrial System Special Funding CARS-43-A-1National Key Research and Development Program of China 2018YFD0502203
6 · The paper itself

Abstract

backgroundSeven in absentia homolog 1 (SIAH1) is an E3 ubiquitin ligase containing a RING-finger domain and a key regulator of normal development. Skin and hair follicle development is a complex and special process of morphogenesis involving multiple signaling pathways. SIAH1 is enriched in the Wnt signaling pathway and potentially related to hair follicle cycle and skin development. This study aims to provide evidence for the role of SIAH1 in skin and hair development.

resultsFull-length cloning and analysis of SIAH1 was conducted to better understand its function. Phylogenetically, the sequence of SIAH1 in the rabbit shares the greatest homology with Home sapiens, Pongo abelii and Mus mulatta. Based on the rabbit hair follicle synchronization model, we found that the expression level of SIAH1 in the regressive period of the rabbit hair cycle is significantly lower than in the active growth and rest periods. In addition, the mRNA expression levels of skin and hair follicle development-related genes changed significantly when SIAH1 was overexpressed and silenced. After SIAH1 overexpression, the expression levels of WNT2, LEF1 and FGF2 decreased, and those of SFRP2 and DKK1 increased (P < 0.05). After interference of SIAH1, the expression levels of WNT2, LEF1 and FGF2 increased (P < 0.05), and SFRP2 and DKK1 decreased.

conclusionsSIAH1 can affect skin and hair follicle development and exert an inhibitory effect. These results could provide foundamental insights into the role of SIAH1 as a target gene in rabbit skin and hair follicle development.

Indexed as

Amino Acid SequenceAnimalsBase SequenceCloning, MolecularDNA, ComplementaryGene Expression ProfilingHairNuclear ProteinsPhylogenyRabbitsSequence AlignmentSkinUbiquitin-Protein LigasesDNA, ComplementaryNuclear ProteinsUbiquitin-Protein LigasesAngora rabbitExpression analysisMolecular cloningSIAH1Skin and hair follicle development

Identifiers

PMID32252830
PMCPMC7137485
OpenAlexW3014887026

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.