Evidence map›Paper›PMID 32252800›Full record

ArticleStem cell research & therapy2020

Hypoxic preconditioning of human urine-derived stem cell-laden small intestinal submucosa enhances wound healing potential.

Xiu-Ru Zhang, Yi-Zhou Huang, Hong-Wei Gao, Yan-Lin Jiang, Jun-Gen Hu, Jin-Kui Pi, An-Jing Chen, Yi Zhang, Li Zhou, Hui-Qi Xie

Abstract read
PubMed Full text at PMC Publisher
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Article in Stem cell research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Trial
  2. [Biological characteristics of urine-derived stem cells duringZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiu-Ru ZhangLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China.
Yi-Zhou HuangLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China.
Hong-Wei GaoLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China.
Yan-Lin JiangLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China.
Jun-Gen HuLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China.
Jin-Kui PiLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China.
An-Jing ChenLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China.
Yi ZhangLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China.
Li ZhouLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China.
Hui-Qi XieLaboratory of Stem Cell and Tissue Engineering, Orthopaedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, No.1 Ke-Yuan-Si-Lu, Gao-Peng-Da-Dao, Chengdu, 610041, Sichuan, China. xiehuiqi@scu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUrine-derived stem cells (USCs) are a valuable stem cell source for tissue engineering because they can be harvested non-invasively. Small intestine submucosa (SIS) has been used as scaffolds for soft tissue repair in the clinic. However, the feasibility and efficacy of a combination of USCs and SIS for skin wound healing has not been reported. In this study, we created a tissue-engineered skin graft, termed the SIS+USC composite, and hypothesized that hypoxic preconditioning would improve its wound healing potential.

methodsUSCs were seeded on SIS membranes to fabricate the SIS+USC composites, which were then cultured in normoxia (21% O

resultsUSCs showed good cell viability and morphology in both normoxia and hypoxic preconditioning groups. In vitro, hypoxic preconditioning enhanced not only the expression of genes related to wound angiogenesis (VEGF and Ang-2) and reepithelialization (bFGF and EGF) but also the secretion of growth factors (VEGF, EGF, and bFGF). In vivo, hypoxic preconditioning significantly improved the wound healing potential of the SIS+USC composites. It enhanced wound angiogenesis at the early stage of wound healing, promoted reepithelialization, and improved the deposition and remodeling of collagen fibers at the late stage of wound healing.

conclusionsTaken together, this study shows that hypoxic preconditioning provides an easy and efficient strategy to enhance the wound healing potential of the SIS+USC composite.

Indexed as

Stem CellsWound HealingHumansHypoxiaIntercellular Signaling Peptides and ProteinsIntestinal MucosaTissue EngineeringIntercellular Signaling Peptides and ProteinsHypoxic preconditioningSmall intestinal submucosaUrine-derived stem cellsWound healing

Identifiers

PMID32252800
PMCPMC7137341

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.