Evidence map›Paper›PMID 32252731›Full record

ArticleBMC musculoskeletal disorders2020

The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis.

Masanori Tsubosaka, Tomoyuki Matsumoto, Satoshi Sobajima, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Masanori TsubosakaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Tomoyuki MatsumotoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Satoshi SobajimaDepartment of Orthopaedic Surgery, Sobajima Clinic, 2-2-6, Aramotokita, Higashiosaka, Osaka, 577-0011, Japan. orthohealing@soba-cli.com.
Takehiko MatsushitaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Hideki IwaguroDepartment of Orthopaedic Surgery, Sobajima Clinic, 2-2-6, Aramotokita, Higashiosaka, Osaka, 577-0011, Japan.
Ryosuke KurodaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Kobe University · JPOsaka Nishi Clinic · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdipose-derived stromal vascular fraction (SVF) cells are a mixed cell population that includes cells with multilineage potential, similar to bone marrow-derived mesenchymal stem cells. Our purpose is to investigate the influence of SVF cells in patients with knee osteoarthritis (OA) and the short-term treatment effects.

methodsFifty-seven patients were enrolled and treated with intra-articular injection of 2.5 × 10

resultsKnee extension angle at 6 and 12 months postoperatively was significantly better than the preoperative angle. Total WOMAC, VAS, and KOOS scores at 1, 3, 6 and 12 months postoperatively were significantly better than preoperative scores. There was no significant difference in hip-knee-ankle angle among the five time periods. T2 mapping values of lateral femur and tibia were significantly higher 12 months postoperatively than preoperatively.

conclusionsThe short-term clinical effects of intra-articular SVF cell injection on knee OA were excellent. Intra-articular SVF cell injection is a novel and innovative approach for treating patients with knee OA.

Indexed as

Mesenchymal Stem Cell TransplantationAdipose TissueAgedFemaleHumansInjections, Intra-ArticularKnee JointMagnetic Resonance ImagingMaleMesenchymal Stem CellsMiddle AgedOsteoarthritis, KneePain MeasurementRadiographyRange of Motion, ArticularTreatment OutcomeAdipose-derived stromal vascular fraction cellsOsteoarthritisStem cellT2 mapping

Identifiers

PMID32252731
PMCPMC7137313
OpenAlexW3014602131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.