ReviewBMC neurology2020
Polymorphous low-grade neuroepithelial tumor of the young: case report and review focus on the radiological features and genetic alterations.
Review in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review and cumulative analysis of clinical properties of BRAF V600E mutations in PLNTY histological samples.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- Radiological and surgical aspects of polymorphous low-grade neuroepithelial tumor of the young (PLNTY).Acta neurologica Belgica · 2023Pooled it
- Neuroradiological features of the polymorphous low-grade neuroepithelial tumor of the young: five new cases with a systematic review of the literature.Neuroradiology · 2022Pooled it
- Article
- From a Polymorphous Low-Grade Neuroepithelial Tumor to a Glioblastoma in an Adult Patient with FGFR3-TACC3 Fusion: A Case Report and Literature Review of the Molecular Profile.Current oncology (Toronto, Ont.) · 2026Review
- Polymorphous low-grade neuroepithelial tumor of the young: a case report.Frontiers in oncology · 2026Article
- Polymorphic low-grade neuroepithelial tumor of the young and treatment of epilepsy: a case report.Frontiers in oncology · 2026Article
- Article
- Imaging features of polymorphous low-grade neuroepithelial tumors of the young: a case series.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Cortically Based Brain Tumors in Children: A Decision-Tree Approach in the Radiology Reading Room.AJNR. American journal of neuroradiology · 2025Review
- Polymorphous low-grade neuroepithelial tumor of the young.Surgical neurology international · 2025Article
- Polymorphous low-grade neuroepithelial tumor of the young: case report and literature review.International journal of clinical and experimental pathology · 2025Article
- Phenotypic and epigenetic heterogeneity in FGFR2-fused glial and glioneuronal tumours.Neuropathology and applied neurobiology · 2024Article
- Metabolism: an important player in glioma survival and development.Discover oncology · 2024Review
- Pediatric-type diffuse low-grade gliomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- MAPK pathway alterations in polymorphous low-grade neuroepithelial tumor of the young: diagnostic considerations.Brain tumor pathology · 2024Article
- Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): Scoping Review of Case Reports and Case Series.Asian journal of neurosurgery · 2024Article
- Diffuse Gliomas withCancers · 2024Review
- Expanding the Imaging Spectrum of Polymorphous Low-Grade Neuroepithelial Tumor of the Young in Children.AJNR. American journal of neuroradiology · 2024Article
- Polymorphous low-grade neuroepithelial tumour of young (PLNTY): the new kid on the block.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA new type of epileptogenic tumor, the polymorphous low-grade neuroepithelial tumor of the young (PLNTY) was firstly reported by Jason T. Huse et al. at 2016. After that, only 1 case of PLNTY was reported by article. The radiological characteristics of PLNTY have not been concluded. The objective of our study was to report 3 cases of PLNTYs in details and to analyze the image characteristics and genetic alterations of PLNTYs by reviewing our cases and articles. CASE PRESENTATION: There were 3 cases diagnosed as PLNTY by pathology in our hospital during the last 10 years, with the average age of 15. They were all suffered from different degrees of epilepsy. All of them underwent magnetic resonance (MR) imaging and 2 of them underwent computer tomography (CT) imaging. The PLNTYs are all appearing as a solid or solid-cystic cortical mass with little mass effect and unclear boundary with normal brain tissue. They are all shown as hyperintensity in T2WI and iso-/hypointensity in T1WI with slight or no enhancement after contract enhanced in MR imaging. The "salt and pepper sign" in T2WI and grit calcification in CT images might be specific characteristics of PLNTY. All of them recovered after excision of the tumors. The gene tests revealed fibroblast growth factor receptors 3 (FGFR3)-TACC3 fusion and FGFR3 amplification in one case, and the B-Raf proto-oncogene (BRAF) V600E mutation in another case.
conclusionIn the image, the partial ill-marginated cortical mass with "salt and pepper sign" in T2WI or grit calcification in CT imaging might be the typical imaging characteristics of PLNTY. We also prove that the BRAF V600E mutation as well as the FGFR2 and FGFR3 have a close relationship with PLNTY.
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