Evidence map›Paper›PMID 32252461›Full record

ArticleMetabolites2020

A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis.

Marc R McCann, Cora E McHugh, Maggie Kirby, Theodore S Jennaro, Alan E Jones, Kathleen A Stringer, Michael A Puskarich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025
    Review
  2. Article
  3. Article
  4. A New Role of NAP1L1 in Megakaryocytes and Human Platelets.International journal of molecular sciences · 2022
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marc R McCannThe NMR Metabolomics Laboratory, Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Cora E McHughThe NMR Metabolomics Laboratory, Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7857-0236
Maggie KirbyDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Theodore S JennaroThe NMR Metabolomics Laboratory, Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Alan E JonesDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Kathleen A StringerThe NMR Metabolomics Laboratory, Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0238-7774
Michael A PuskarichDepartment of Emergency Medicine, University of Minnesota, Minneapolis, MN 55455, USA.

Funding

L-Carnitine Pharmacometabolomics in Sepsis (CaPS)R01GM111400 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STRINGER, KATHLEEN A · 2016 to 2019
$1.2M
Platelet activation in septic shockK23GM113041 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI PUSKARICH, MICHAEL A. · 2015 to 2018
$763k
National Institute of General Medical Sciences, National Institutes of Health K23GM113041 and GM111400NIGMS NIH HHS R01 GM111400
6 · The paper itself

Abstract

backgroundSepsis-induced alterations in mitochondrial function contribute to organ dysfunction and mortality. Measuring mitochondrial function in vital organs is neither feasible nor practical, highlighting the need for non-invasive approaches. Mitochondrial function may be reflected in the concentrations of metabolites found in platelets and whole blood (WB) samples. We proposed to use these as alternates to indirectly estimate platelet mitochondrial oxygen consumption rate (mOCR) in sepsis patients.

methodsWe determined the relationships between platelet mOCR and metabolites in both platelets and WB, as measured by quantitative

resultsThe differences in adjusted-R

conclusionsOur data suggest there are groups of metabolites in WB (leucine, acetylcarnitine) and platelets (creatine, ADP, glucose, taurine) that are associated with platelet mOCR. Thus, WB and platelet metabolites could be used to estimate platelet mOCR.

Indexed as

acetylcarnitinebioenergeticsmetabolismmitochondriamitochondrial functionmitochondrial respirationnuclear magnetic resonance spectroscopy

Identifiers

PMID32252461
PMCPMC7240966

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.