Evidence map›Paper›PMID 32252439›Full record

ArticleInternational journal of molecular sciences2020

Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells-Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy.

She-Hung Chan, Wohn-Jenn Leu, Sharada Prasanna Swain, Jui-Ling Hsu, Duen-Ren Hou, Jih-Hwa Guh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

She-Hung ChanDepartment of Cosmetic Science, Providence University, 200, Sec. 7, Taiwan Boulevard, Shalu Dist., Taichung 43301, Taiwan.ORCID 0000-0003-0356-4656
Wohn-Jenn LeuSchool of Pharmacy, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.
Sharada Prasanna SwainDepartment of Chemistry, National Central University, No. 300 Jhong-Da Road, Jhong-li, Taoyuan 32001, Taiwan.ORCID 0000-0002-9708-9376
Jui-Ling HsuSchool of Pharmacy, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.
Duen-Ren HouDepartment of Chemistry, National Central University, No. 300 Jhong-Da Road, Jhong-li, Taoyuan 32001, Taiwan.
Jih-Hwa GuhSchool of Pharmacy, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.
National Taiwan University · TWNational Central University · TW

Funding

Ministry of Science and Technology in Taiwan MOST107-2320-B-002-018-MY3, MOST106-2320-B-126-001-MY2
6 · The paper itself

Abstract

Various derivatives that mimic ceramide structures by introducing a triazole to connect the aminodiol moiety and long alkyl chain have been synthesized and screened for their anti-leukemia activity. SPS8 stood out among the derivatives, showing cytotoxic selectivity between leukemic cell lines and human peripheral blood mononuclear cells (about ten times). DAPI nuclear staining and H&E staining revealed DNA fragmentation under the action of SPS8. SPS8 induced an increase in intracellular Ca

Indexed as

Antineoplastic AgentsApoptosisAutophagyCalciumCell Line, TumorCell SurvivalGene Regulatory NetworksHL-60 CellsHumansLeukemiaMitochondriaModels, BiologicalMolecular StructureSignal TransductionStress, PhysiologicalTranscription, GeneticAntineoplastic AgentsCalciumTriazolesautophagyleukemic cellsmitochondrial damageSTAT3triazole based aminodiol derivative

Identifiers

PMID32252439
PMCPMC7177546
OpenAlexW3015116689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.