Evidence map›Paper›PMID 32252412›Full record

ArticleJournal of functional biomaterials2020

Cytotoxic Effects of Plant Sap-Derived Extracellular Vesicles on Various Tumor Cell Types.

Kimin Kim, Hye Ju Yoo, Jik-Han Jung, Ruri Lee, Jae-Kyung Hyun, Ji-Ho Park, Dokyun Na, Ju Hun Yeon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 94 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kimin KimDepartment of Integrative Biosciences, University of Brain Education, Cheonan 31228, Korea.
Hye Ju YooDepartment of Integrative Biosciences, University of Brain Education, Cheonan 31228, Korea.
Jik-Han JungDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34051, Korea.
Ruri LeeDepartment of Integrative Biosciences, University of Brain Education, Cheonan 31228, Korea.
Jae-Kyung HyunElectron Microscopy Research Center, Korea Basic Science Institute, Cheongju 28119, Korea.
Ji-Ho ParkDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34051, Korea.
Dokyun NaSchool of Integrative Engineering, Chung-Ang University, Seoul 06911, Korea.
Ju Hun YeonDepartment of Integrative Biosciences, University of Brain Education, Cheonan 31228, Korea.
University of Brain Education · KRKorea Advanced Institute of Science and Technology · KRChung-Ang University · KRKorea Basic Science Institute · KR

Funding

National Research Foundation of Korea NRF-2016R1C1B2013345
6 · The paper itself

Abstract

Edible plants have been widely used in traditional therapeutics because of the biological activities of their natural ingredients, including anticancer, antioxidant, and anti-inflammatory properties. Plant sap contains such medicinal substances and their secondary metabolites provide unique chemical structures that contribute to their therapeutic efficacy. Plant extracts are known to contain a variety of extracellular vesicles (EVs) but the effects of such EVs on various cancers have not been investigated. Here, we extracted EVs from four plants-Dendropanax morbifera, Pinus densiflora, Thuja occidentalis, and Chamaecyparis obtusa-that are known to have cytotoxic effects. We evaluated the cytotoxic effects of these EVs by assessing their ability to selectively reduce the viability of various tumor cell types compared with normal cells and low metastatic cells. EVs from D. morbifera and P. densiflora sap showed strong cytotoxic effects on tumor cells, whereas those from T. occidentalis and C. obtusa had no significant effect on any tumor cell types. We also identified synergistic effect of EVs from D. morbifera and P. densiflora saps on breast and skin tumor cells and established optimized treatment concentrations. Our findings suggest these EVs from plant sap as new candidates for cancer treatment.

Indexed as

cytotoxic effectsextracellular vesiclesplant sapselective toxicitysynergistic effect

Identifiers

PMID32252412
PMCPMC7353476
OpenAlexW3014139463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.