ArticleDiagnostics (Basel, Switzerland)2020
Cervical Lymph Node Metastases in Oral Squamous Cell Carcinoma-How Much Imaging Do We Need?
Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Diagnostic imaging modalities to detect regional nodal involvement in oral squamous cell carcinoma: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- Identification of potential biomarkers for oral squamous cell carcinoma through multi-cohort bioinformatic analysis.Journal of the Egyptian National Cancer Institute · 2026Article
- Beyond the T: Volumetric MRI Predicts Lymphatic Spread in Oral Squamous Cell Carcinoma.Cancers · 2026Article
- Clinical and molecular characterizations of HNSCC patients with occult lymph node metastasis.Scientific reports · 2025Article
- Comparing the Efficacy of CT, MRI, PET-CT, and US in the Detection of Cervical Lymph Node Metastases in Head and Neck Squamous Cell Carcinoma with Clinically Negative Neck Lymph Node: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Head and Neck Squamous Cell Carcinoma: Insights from Dual-Energy Computed Tomography (DECT).Tomography (Ann Arbor, Mich.) · 2024Review
- Predictors of Occult Metastasis and Prognostic Factors in Patients with cN0 Oral Cancer Who Underwent Elective Neck Dissection.Diseases (Basel, Switzerland) · 2024Article
- Radiomics from dual-energy CT-derived iodine maps predict lymph node metastasis in head and neck squamous cell carcinoma.La Radiologia medica · 2024Article
- Article
- Diagnostic accuracy of contrast-enhanced computed tomography in assessing cervical lymph node status in patients with oral squamous cell carcinoma.Journal of cancer research and clinical oncology · 2023Article
- Diagnostic Accuracy of Up-Front PET/CT and MRI for Detecting Cervical Lymph Node Metastases in T1-T2 Oral Cavity Cancer-A Prospective Cohort Study.Diagnostics (Basel, Switzerland) · 2023Article
- A preoperative nomogram model for the prediction of lymph node metastasis in buccal mucosa cancer.Cancer medicine · 2023Article
- The role of magnetic resonance imaging and computed tomography in oral squamous cell carcinoma patients' preoperative staging.Frontiers in oncology · 2023Article
- A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma.International journal of cancer · 2022Article
- Preoperative Prediction of the Aggressiveness of Oral Tongue Squamous Cell Carcinoma with Quantitative Parameters from Dual-Energy Computed Tomography.Frontiers in oncology · 2022Article
- Extent of Neck Dissection and Cervical Lymph Node Involvement in Oral Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Pretreatment Blood Markers in the Prediction of Occult Neck Metastasis: A 10-Year Retrospective Study.Cureus · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical lymph node metastases in oral squamous cell carcinoma (OSCC) are key predictors of disease specific survival. It was therefore the aim of this study to evaluate how much imaging is minimally needed for reliable and efficient identification of cervical lymph node metastases. In this retrospective cross-sectional study, results (metastasis yes/no) of ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) were compared to the final histopathological results of the corresponding neck dissection (ND) specimens (metastasis yes/no). A score was calculated to account for cervical lymph node size, shape, clustering, peripheral enhancement, hilus sign, architecture, blood flow, and central necrosis. Sensitivity and specificity were analyzed for each imaging technique separately. In 164 patients diagnosed with OSCC, 96 underwent uni- or bilateral ND (122 ND in total). One hundred percent sensitivity was achieved by CT+MRI, MRI+PET, US+CT+MRI, US+MRI+PET, CT+MRI+PET, and US+CT+MRI+PET. The highest specificity was realized by US with 79% (95% CI [0.698-0.890]). Specificity for CT+MRI and PET+MRI was 51% (95% CI [0.359-0.665]) and 70% (95% CI [0.416-0.984]), respectively. Regarding 100% sensitivity with acceptable specificity, the combination of CT+MRI or PET+MRI appeared to be suitable for staging cervical lymph nodes in primary OSCC.
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