Evidence map›Paper›PMID 32252376›Full record

ReviewToxins2020

Impact of Bacterial Toxins in the Lungs.

Rudolf Lucas, Yalda Hadizamani, Joyce Gonzales, Boris Gorshkov, Thomas Bodmer, Yves Berthiaume, Ueli Moehrlen, Hartmut Lode, Hanno Huwer, Martina Hudel and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Benzo[RSC advances · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Neutrophilic inflammation in bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  10. Article
  11. Article
  12. The Comparative Characterization of a HypervirulentInternational journal of molecular sciences · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Innate immune responses in pneumonia.Pneumonia (Nathan Qld.) · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Rudolf LucasPharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Yalda HadizamaniLungen-und Atmungsstiftung, Bern, 3012 Bern, Switzerland.
Joyce GonzalesDepartment of Medicine and Division of Pulmonary Critical Care Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Boris GorshkovVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Thomas BodmerLabormedizinisches Zentrum Dr. Risch, Waldeggstr. 37 CH-3097 Liebefeld, Switzerland.
Yves BerthiaumeDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Ueli MoehrlenPediatric Surgery, University Children's Hospital, Zürich, Steinwiesstrasse 75, CH-8032 Zürch, Switzerland.
Hartmut LodeInsitut für klinische Pharmakologie, Charité, Universitätsklinikum Berlin, Reichsstrasse 2, D-14052 Berlin, Germany.
Hanno HuwerDepartment of Cardiothoracic Surgery, Voelklingen Heart Center, 66333 Voelklingen/Saar, Germany.
Martina HudelJustus-Liebig-University, Biomedical Research Centre Seltersberg, Schubertstr. 81, 35392 Giessen, Germany.
Mobarak Abu MraheilJustus-Liebig-University, Biomedical Research Centre Seltersberg, Schubertstr. 81, 35392 Giessen, Germany.
Haroldo Alfredo Flores ToquePharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.
Trinad ChakrabortyJustus-Liebig-University, Biomedical Research Centre Seltersberg, Schubertstr. 81, 35392 Giessen, Germany.
Jürg HamacherLungen-und Atmungsstiftung, Bern, 3012 Bern, Switzerland.
Augusta University · USJustus-Liebig-Universität Gießen · DELindenhofspital · CHCharité - Universitätsmedizin Berlin · DELabormedizinische Zentrum Dr Risch (Switzerland) · CHSaarstahl (Germany) · DEUniversité de Montréal · CAUniversity Children's Hospital Zurich · CH

Funding

ENaC-α mediates lung fluid clearance and capillary barrier function in pneumoniaR01HL138410 · NHLBI · AUGUSTA UNIVERSITY · PI LUCAS, RUDOLF · 2018 to 2021
$2.0M
NHLBI NIH HHS R01 HL138410
6 · The paper itself

Abstract

Bacterial toxins play a key role in the pathogenesis of lung disease. Based on their structural and functional properties, they employ various strategies to modulate lung barrier function and to impair host defense in order to promote infection. Although in general, these toxins target common cellular signaling pathways and host compartments, toxin- and cell-specific effects have also been reported. Toxins can affect resident pulmonary cells involved in alveolar fluid clearance (AFC) and barrier function through impairing vectorial Na

Indexed as

Adaptive ImmunityAnimalsBacteriaBacterial InfectionsBacterial ToxinsDisease ProgressionHost-Pathogen InteractionsHumansImmunity, InnateLungRespiratory Tract InfectionsSignal TransductionBacterial Toxinsalveolar-capillary barrieralveolar liquid clearancebacterial toxinshost defenseinflammationpulmonary edema

Identifiers

PMID32252376
PMCPMC7232160
OpenAlexW3014977212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.