ArticleInternational journal of environmental research and public health2020
Perinatal and Antibiotic Exposures and the Risk of Developing Childhood-Onset Inflammatory Bowel Disease: A Nested Case-Control Study Based on a Population-Based Birth Cohort.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Systematic review and meta-analysis of childhood exposure to antibiotics and the subsequent risk of IBD.Inflammatory bowel diseases · 2026Pooled it
- Role of complete blood count in the diagnosis of culture-proven neonatal sepsis: a systematic review and meta-analysis.Archives of disease in childhood · 2025Pooled it
- Early life antibiotics and childhood gastrointestinal disorders: a systematic review.BMJ paediatrics open · 2021Pooled it
- Pre-Diagnosis Dietary Pattern Differences in Australian Children with Inflammatory Bowel Disease: Exposure Across Ethnicities.Nutrients · 2026Article
- Mode of birth and risk of inflammatory bowel disease in offspring: an updated systematic review and meta-analysis.Frontiers in reproductive health · 2026Review
- Do Antibiotics Cause Inflammatory Bowel Disease? A Systematic Review and Meta-Analysis.Visceral medicine · 2025Review
- Impact of maternal organic food consumption and diet quality during pregnancy on offspring's risk of inflammatory bowel disease: findings from a Danish National Birth Cohort Study.Frontiers in nutrition · 2025Article
- Parental and perinatal risk factors associated with onset of IBD: a systematic literature review and meta-analysis.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Review
- Early-Life Infections, Antibiotics and Later Risk of Childhood and Early Adult-Onset Inflammatory Bowel Disease: Pooled Analysis of Two Scandinavian Birth Cohorts.Alimentary pharmacology & therapeutics · 2025Article
- Childhood Socioeconomic Characteristics and Risk of Inflammatory Bowel Disease: A Scandinavian Birth Cohort Study.Inflammatory bowel diseases · 2024Article
- Eosinophils, Eosinophilic Gastrointestinal Diseases, and Inflammatory Bowel Disease: A Critical Review.Journal of clinical medicine · 2024Review
- Fetal and Early-Life Antibiotics and Risk of Pediatric Inflammatory Bowel Disease: A Population-Based Nationwide Register Study.Journal of pediatrics. Clinical practice · 2024Article
- An Overview of Antibiotic Therapy for Early- and Late-Onset Neonatal Sepsis: Current Strategies and Future Prospects.Antibiotics (Basel, Switzerland) · 2024Review
- Amyloid, Crohn's disease, and Alzheimer's disease - are they linked?Frontiers in cellular and infection microbiology · 2024Review
- Procalcitonin-Based Antibiotic Use for Neonatal Early-Onset Bacterial Infections: Pre- and Post-Intervention Clinical Study.Antibiotics (Basel, Switzerland) · 2023Article
- Promoting early testing and appropriate referral to reduce diagnostic delay for children with suspected inflammatory bowel disease, a narrative review.Translational pediatrics · 2023Review
- Article
- Implications of the changing epidemiology of inflammatory bowel disease in a changing world.United European gastroenterology journal · 2022Review
- Environmental Risk Factors for Childhood Inflammatory Bowel Diseases: A Multicenter Case-Control Study.Children (Basel, Switzerland) · 2022Article
- MaternalFASEB bioAdvances · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of early-life environmental exposures on Inflammatory Bowel Disease (IBD) onset remains unclear. We aimed to quantify the impact of perinatal conditions and antibiotic use in the first 6 and 12 months of life, on the risk of childhood-onset IBD, in a birth cohort of the region Friuli-Venezia Giulia (Italy). A nested case-control design on a longitudinal cohort of 213,515 newborns was adopted. Conditional binomial regression models were used to estimate Odds Ratios (OR) with 95% confidence intervals (CI) for all analyzed risk factors. We identified 164 individuals with IBD onset before the age of 18 years and 1640 controls. None of the considered perinatal conditions were associated with IBD. Analyses on antibiotic exposure were based on 70 cases and 700 controls. Risks were significantly higher for children with ≥4 antibiotic prescriptions in the first 6 and 12 months of life (OR = 6.34; 95%CI 1.68-24.02 and OR = 2.91; 95%CI 1.31-6.45, respectively). This association was present only among patients with Crohn's disease and those with earlier IBD onset. We found that perinatal characteristics were not associated to IBD, while the frequent use of antibiotics during the first year of life was associated to an increased risk of developing subsequent childhood-onset IBD.
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