ArticleClinical and experimental pediatrics2020
Association between assisted reproductive technology and autism spectrum disorders in Iran: a case-control study.
Article in Clinical and experimental pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association of assisted reproductive technology with autism spectrum disorder in the offspring: an updated systematic review and meta-analysis.European journal of pediatrics · 2021Pooled it
- Risk Factors for Autism Spectrum Disorder in the Middle East and North Africa Region: A Systematic Review and Meta-Analysis of Confounder-Adjusted Studies.Journal of autism and developmental disorders · 2026Article
- Factors associated with abnormal screening for autism spectrum disorder among Extremely Preterm Children.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neurodevelopmental Outcomes of Pregnancies Resulting from Assisted Reproduction: A Review of the Literature.Children (Basel, Switzerland) · 2022Review
- Is fetal nuchal cord associated with autism spectrum disorder? A meta-analysis.Clinical and experimental pediatrics · 2022Article
- The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution.Frontiers in cell and developmental biology · 2022Review
- Association between small for gestational age and risk of autism spectrum disorders: a meta-analysis.Clinical and experimental pediatrics · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder defined by impairments in social interaction and verbal and nonverbal communication. PURPOSE: Determine the association between use of assisted reproduction technology (ART) and the risk of ASD among children.
methodsThis case-control study included 300 participants (100 cases, 200 controls). The control group included women with a child aged 2-10 years without ASD, while the cases were women with a child aged 2-10 years with ASD. We used a researcher-made questionnaire. Data were analyzed using Stata ver. 14 at the 0.05 significance level.
resultsIn the univariate analysis, there was significant association between child sex, delivery mode, history of preterm delivery, history of using ART, and maternal age at child's birth and the risk of ASD. After the adjustment for other variables, this association was significant for male sex (2.66; 95% confidence interval [CI], 1.11-4.31; P=0.001) and history of using ART (4.03; 95% CI, 1.76-9.21; P=0.001). Therefore, after the adjustment for confounder variables, there was no significant association between ART and the risk of ASD among children (4.98; 95% CI, 0.91-27.30; P=0.065).
conclusionAfter the adjustment for other variables, risk factors for ASD were male sex and history preterm delivery. Thus, there was no significant association between ART and the risk of ASD among children.
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Registered trials
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