Evidence map›Paper›PMID 32251917›Full record

SynthesisJournal of psychiatric research2020

Transcranial magnetic stimulation to reduce suicidality - A review and naturalistic outcomes.

Melanie L Bozzay, Jennifer Primack, Jennifer Barredo, Noah S Philip

Registry-linked trialOpen access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Journal of psychiatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03952468 (Combined Transcranial Magnetic Stimulation and Brief Cognitive Therapy to Reduce Suicide Behavior in High-Risk Veterans), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03952468 nacompletednot on this map

Combined Transcranial Magnetic Stimulation and Brief Cognitive Therapy to Reduce Suicide Behavior in High-Risk Veterans

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2019 to 2024Enrolled55ConditionsSuicideArmsTranscranial Magnetic Stimulation, Brief Cognitive Behavioral Therapy
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  5. Clinical effects and correlates of standard rTMS and theta burst stimulation (TBS) on suicidal ideation in late-life depression.European psychiatry : the journal of the Association of European Psychiatrists · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Melanie L BozzayDepartment of Psychiatry & Human Behavior, Alpert Medical School of Brown University, Providence RI, USA; VA RR&D Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence RI, USA.
Jennifer PrimackDepartment of Psychiatry & Human Behavior, Alpert Medical School of Brown University, Providence RI, USA; VA RR&D Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence RI, USA.
Jennifer BarredoDepartment of Psychiatry & Human Behavior, Alpert Medical School of Brown University, Providence RI, USA; VA RR&D Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence RI, USA.
Noah S PhilipDepartment of Psychiatry & Human Behavior, Alpert Medical School of Brown University, Providence RI, USA; VA RR&D Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence RI, USA. Electronic address: Noah_Philip@brown.edu.
Brown University · USProvidence VA Medical Center · US

Funding

Neuroimaging and Neuromodulation CoreP20GM130452 · NIGMS · BUTLER HOSPITAL (PROVIDENCE, RI) · PI GREENBERG, BENJAMIN D · 2019 to 2023
$11.3M
Combined Transcranial Magnetic Stimulation and Brief Cognitive Therapy to Reduce Veteran SuicideI01HX002572 · VA · PROVIDENCE VA MEDICAL CENTER · PI PHILIP, NOAH STEPHEN, PRIMACK, JENNIFER MARIE · 2019 to 2024
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Combined Transcranial Direct Current Stimulation and Virtual Reality for PTSDI01RX002450 · VA · PROVIDENCE VA MEDICAL CENTER · PI PHILIP, NOAH STEPHEN · 2018 to 2022
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Identification of Veterans at-risk for Suicide: a Multidisciplinary ApproachIK2CX001824 · VA · PROVIDENCE VA MEDICAL CENTER · PI BARREDO, JENNIFER LEIGH · 2019 to 2024
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CSRD VA IK2 CX001824HSRD VA I01 HX002572NIGMS NIH HHS P20 GM130452RRD VA I01 RX002450
6 · The paper itself

Abstract

Although there is growing interest in the use of repetitive Transcranial Magnetic Stimulation (TMS) as a treatment for suicidality, efficacy data in this area, and knowledge of potential treatment mechanisms, remains limited. The first objective of this study was to systematically review clinical trial data examining the effectiveness of TMS as a treatment for suicidal ideation. Our secondary objective was to investigate the extent to which changes in suicidality are independent of improvements in depression in a clinical sample of veterans who received TMS treatment. In Study 1, we searched the Pubmed and biRxiv databases from inception until July 2019 to identify studies that examined the efficacy of TMS for suicidal thoughts and/or behaviors. Data regarding sample characteristics, treatment parameters, and results were synthesized from six randomized controlled trials and five unblinded trials (total n = 593). Our systematic review indicated that while TMS was consistently associated with reduced depression, its impact on suicidality is unclear. Interpretation of results related to suicidality were complicated by study design elements and modest sample sizes. In Study 2, we conducted a retrospective analysis of 43 patients who received care for depression in a neuromodulation clinic at a Veteran's Affairs hospital. Results found significant decreases in suicidal ideation, and depressive symptom change did not always account for improvements in ideation. Taken together, our literature review and clinic study indicate preliminary promise of TMS for suicide, and underscore the need for more fine-grained, suicide-specific TMS research.

Indexed as

Suicide PreventionTranscranial Magnetic StimulationHumansRetrospective StudiesSuicidal IdeationBrain stimulationDepressionSuicideTheta burst stimulationTranscranial magnetic stimulation

Identifiers

PMID32251917
PMCPMC7197489
OpenAlexW3014071089

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.