ArticleNeuroImage. Clinical2020
Temporal lobe epilepsy alters spatio-temporal dynamics of the hippocampal functional network.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Functional connectivity of hippocampus in temporal lobe epilepsy depends on hippocampal dominance: a systematic review of the literature.Journal of neurology · 2022Pooled it
- Dynamic limbic-executive decoupling underpins the reciprocal link between drug-resistant state and depression in temporal lobe epilepsy.Epilepsia · 2026Article
- Disparities in Connectivity Profiles Between Structural and Functional Networks in Patients With Temporal Lobe Epilepsy.Brain and behavior · 2025Article
- Motor and default mode network states of rest in frontal lobe epilepsy.Neuroimage. Reports · 2025Article
- The network neuropsychology of juvenile myoclonic epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Aberrant functional connectivity of amygdala subregions in temporal lobe epilepsy with ictal panic.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Aberrant white matter and subcortical gray matter functional network connectivity associated with static and dynamic characteristics in subjects with temporal lobe epilepsy.Frontiers in neuroscience · 2025Article
- Dynamic functional connectivity and gene expression correlates in temporal lobe epilepsy: insights from hidden markov models.Journal of translational medicine · 2024Article
- Alterations in static and dynamic regional homogeneity in mesial temporal lobe epilepsy with and without initial precipitating injury.Frontiers in neuroscience · 2023Article
- Brain structural connectivity sub typing in unilateral temporal lobe epilepsy.Brain imaging and behavior · 2022Article
- Changes in the Brain in Temporal Lobe Epilepsy with Unilateral Hippocampal Sclerosis: An Initial Case Series.Healthcare (Basel, Switzerland) · 2022Article
- Sequential Semiology of Seizures and Brain Perfusion Patterns in Patients with Drug-Resistant Focal Epilepsies: A Perspective from Neural Networks.Behavioral sciences (Basel, Switzerland) · 2022Article
- More than just statics: Static and temporal dynamic changes in intrinsic brain activity in unilateral temporal lobe epilepsy.Frontiers in human neuroscience · 2022Article
- Network connectivity predicts effectiveness of responsive neurostimulation in focal epilepsy.Brain communications · 2022Article
- Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy.Nature reviews. Neurology · 2021Review
- Regional and global resting-state functional MR connectivity in temporal lobe epilepsy: Results from the Epilepsy Connectome Project.Epilepsy & behavior : E&B · 2021Article
- Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond.Frontiers in neural circuits · 2021Review
- Decreased Intrinsic Neural Timescales in Mesial Temporal Lobe Epilepsy.Frontiers in human neuroscience · 2021Article
- Abnormal Static and Dynamic Functional Connectivity in Left and Right Temporal Lobe Epilepsy.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Mesial temporal lobe epilepsy (TLE) is characterized by transient abnormal electrical activity originating in the hippocampus. The objective of this study was to characterize dynamic spatio-temporal fluctuations in hippocampal network connectivity in mTLE using functional connectivity (FC) mapping in 41 unilateral mTLE patients (28 right, 13 left) and 56 healthy control participants using 3T MRI. Dynamic FC was computed across the scan using sliding 60-s windows. This was compared to static FC computed using the whole 10-min functional MRI scan, and to the variance in the hippocampal functional MRI signal. Four states of healthy hippocampal dynamic FC were identified and compared to TLE patients. TLE patients fluctuated between these four states, but the hippocampus ipsilateral to the seizure focus spent more time in a state distinguished by lower prefrontal and parietal FC than the dominant healthy state. Increased time spent in this state was associated with increased impairment in static FC and increased variance in the hippocampal functional MRI signal. Overall, this work provides evidence that increases in variance in signal fluctuations occurring at the seizure focus in the hippocampus in patients with mTLE may contribute to disruptions in healthy FC network dynamics within an fMRI scan that contribute to decreases in static hippocampal FC. These alterations result in decreased hippocampal connectivity to bilateral prefrontal and parietal regions in TLE which may be related to behavior and cognitive impairments in these patients. Therefore, characterization of an individual patient's hippocampal dynamics at different time scales may provide more specific spatio-temporal profiles of network impairment that may be related to hippocampal dysfunction in TLE.
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Registered trials
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