Evidence map›Paper›PMID 32251646›Full record

ArticleExperimental neurology2020

Response of hypogastric afferent fibers to bladder distention or irritation in cats.

Wenbin Guo, Katherine Shapiro, Zhaoxia Wang, Natalie Pace, Haotian Cai, Bing Shen, Jicheng Wang, William C de Groat, Changfeng Tai, Jonathan M Beckel

Open access · greenAbstract read
In one paragraph

Article in Experimental neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Wenbin GuoDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, PR China.
Katherine ShapiroDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Zhaoxia WangDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA; Rehabilitation School of Capital Medical University, Department of Urology, Rehabilitation Research Centre, Beijing, PR China.
Natalie PaceDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Haotian CaiDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA; School of Health and Rehabilitation Science, University of Pittsburgh, PA, USA.
Bing ShenDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Jicheng WangDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
William C de GroatDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Changfeng TaiDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Jonathan M BeckelDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: jmbeckel@pitt.edu.
University of Pittsburgh · US

Funding

Parasympathetic and sympathetic mechanisms underlying bladder nociceptionR01DK111382 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKEL, JONATHAN M · 2017 to 2020
$1.4M
Neuromodulation for Non-Obstructive Urinary Retention (NOUR)R01DK121698 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAI, CHANGFENG · 2019 to 2021
$704k
NIDDK NIH HHS R01 DK111382NIDDK NIH HHS R01 DK121698
6 · The paper itself

Abstract

The goal of this study in anesthetized cats was to identify silent hypogastric nerve (HGN) afferent fibers that do not respond to bladder distention but become responsive after chemical irritation of the bladder. The HGN was split into multiple filaments small enough for recording action potentials from single or multiple afferent fibers. The bladder was distended by infusion of either saline or 0.5% acetic acid (AA) through a urethral catheter while recording intravesical pressure. A total of 90 HGN filaments from 17 cats responded to bladder distention with saline or AA. Three types of HGN afferents were identified. The first type was non-nociceptive mechano-sensitive that responded to bladder distention at normal physiological pressures (10-40 cmH

Indexed as

Action PotentialsAfferent PathwaysAnimalsCatsFemaleHypogastric PlexusMaleNeurons, AfferentSaline SolutionUrinary BladderUrinary Bladder DiseasesSaline SolutionBladderCatHypogastric nerveNociception

Identifiers

PMID32251646
PMCPMC7237284
OpenAlexW3014265381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.