Evidence map›Paper›PMID 32251580›Full record

ArticleBiochemistry2020

Biochemical Characterization of Yeast Xrn1.

Conner J Langeberg, William R W Welch, John V McGuire, Alison Ashby, Alexander D Jackson, Erich G Chapman

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Conner J LangebergDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.ORCID 0000-0002-5609-3758
William R W WelchDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.
John V McGuireDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.
Alison AshbyDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.
Alexander D JacksonDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.
Erich G ChapmanDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, United States.ORCID 0000-0002-5321-9095
University of Denver · US

Funding

RNAs that Resist Degradation in the Cell and the Manipulation of RNA Stability in Living OrganismsR00GM115757 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI CHAPMAN, ERICH G · 2016 to 2018
$746k
NIGMS NIH HHS R00 GM115757
6 · The paper itself

Abstract

Messenger RNA degradation is an important component of overall gene expression. During the final step of eukaryotic mRNA degradation, exoribonuclease 1 (Xrn1) carries out 5' → 3' processive, hydrolytic degradation of RNA molecules using divalent metal ion catalysis. To initiate studies of the 5' → 3' RNA decay machinery in our lab, we expressed a C-terminally truncated version of

Indexed as

ExoribonucleasesHydrogen-Ion ConcentrationModels, MolecularSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsExoribonucleasesSaccharomyces cerevisiae ProteinsXRN1 protein, S cerevisiae

Identifiers

PMID32251580
PMCPMC7780157
OpenAlexW3014130795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.