Observational studyPloS one2020
Estimated glomerular filtration rate predicts 30-day mortality in medical emergency departments: Results of a prospective multi-national observational study.
Observational study in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- The influence of hypoxia in predicting COVID-19 mortality in patients with kidney dysfunction on admission in 2 centers in sub-Saharan Africa.Renal failure · 2026Article
- Interaction between oxygen saturation and renal function on 30-day mortality in emergency department patients.Scientific reports · 2026Article
- Postoperative mortality in renal cell carcinoma with vena cava thrombus in the elderly population (uroCCR study n°192).World journal of urology · 2025Article
- Evaluating NT-proBNP-to-Albumin (NTAR) and RDW-to-eGFR (RGR) Ratios as Biomarkers for Predicting Hospitalization Duration and Mortality in Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH).Diagnostics (Basel, Switzerland) · 2025Article
- Early Urine Output in the Emergency Room as a Prognostic Indicator for Critically Ill Patients Undergoing Continuous Renal Replacement.Life (Basel, Switzerland) · 2025Article
- Prognostic factors for hospitalization for severe hypoglycemia without diabetes mellitus: a retrospective study.Diabetology international · 2024Article
- Trajectory pattern of serially measured acute kidney injury biomarkers in critically ill patients: a prospective observational study.Annals of intensive care · 2024Article
- Addition of bioimpedance-derived body cell mass improves performance of serum creatinine-based GFR estimation in a chronic kidney disease cohort.International urology and nephrology · 2024Article
- Association of estimated glomerular filtration rate and all-cause mortality in acute pancreatitis: a retrospective analysis.BMC anesthesiology · 2023Article
- Diagnostic and Prognostic Roles of C-Reactive Protein, Procalcitonin, and Presepsin in Acute Kidney Injury Patients Initiating Continuous Renal Replacement Therapy.Diagnostics (Basel, Switzerland) · 2023Article
- Observational
- The use of chest ultrasonography in suspected cases of COVID-19 in the emergency department.Future science OA · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal failure is common in patients seeking help in medical emergency departments. Decreased renal function is associated with increased mortality in patients with heart failure or sepsis. In this study, the association between renal function (reflected by estimated glomerular filtration rate (eGFR) at the time of admission) and clinical outcome was evaluated. METHODS/
objectivesData was used from a prospective, multi-national, observational cohort of patients treated in three medical emergency departments of tertiary care centers. The eGFR was calculated from the creatinine at the time of admission (using the Chronic Kidney Disease-Epidemiology Collaboration equation,CKD-EPI). Uni- and multivariate regression models were used for eGFR and 30-day mortality, in hospital mortality, length of stay and intensive care unit admission rate.
results6983 patients were included. The 30-day mortality was 1.8%, 3.5%, 6.9%, 11.1%, 13.6%, and 14.2% in patients with eGFR of above 90, 60-89, 45-59, 30-44, 15-29, and <15 ml/min/1.73m2, respectively. Using multivariate regression, the adjusted odds ratio (OR) was 2.31 (for 15-29 ml/min/1.73m2, 95% confidence interval 1.36 to 3.90, p = 0.002) and 3.73 (for eGFR <15ml/min/1.73m2 as compared to >90 ml/min/1.73m2, 95% CI 2.04 to 6.84, p<0.001). For 10 ml/min/1.73m2 decrease in eGFR the OR for the 30-day mortality was 1.15 (95% CI1.09 to 1.22, p<0.001).The eGFR was also significantly associated with in-hospital mortality, the percentage of ICU-admissions, and with a longer hospital stay. No association was found with hospital readmission within 30 days. As limitations, only eGFR at admission was available and the number of patients on hemodialysis was unknown.
conclusionReduced eGFR at the time of admission is a strong and independent predictor for adverse outcome in this large population of patients admitted to medical emergency departments.
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