Evidence map›Paper›PMID 32251434›Full record

ArticlePloS one2020

Bovistol B, bovistol D and strossmayerin: Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri.

Alice M Banks, Lijiang Song, Gregory L Challis, Andy M Bailey, Gary D Foster

Abstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alice M BanksSchool of Biological Sciences, University of Bristol, Bristol, United Kingdom.ORCID 0000-0001-6711-9186
Lijiang SongDepartment of Chemistry, University of Warwick, Coventry, United Kingdom.
Gregory L ChallisDepartment of Chemistry, University of Warwick, Coventry, United Kingdom.
Andy M BaileySchool of Biological Sciences, University of Bristol, Bristol, United Kingdom.
Gary D FosterSchool of Biological Sciences, University of Bristol, Bristol, United Kingdom.

Funding

Biotechnology and Biological Sciences Research Council BB/K002341/1Biotechnology and Biological Sciences Research Council BB/L01386X/1
6 · The paper itself

Abstract

Basidiomycete fungi are a rich source of natural products with a diverse array of potentially exploitable bioactivities. Two dimeric sesquiterpenes, bovistol B (1) and D (2), and one monomeric sesquiterpene, strossmayerin (7), were isolated from the culture filtrate of the basidiomycete fungus Coprinopsis strossmayeri. The structures were determined through a combination of MS and 1D/2D NMR spectroscopic techniques. Likely monomeric precursors, identified on the basis of HRMS analysis, allow a plausible biosynthetic pathway to be proposed for the biosynthesis of 1 and 2, involving the dimerisation of the monomer through a hetero-Diels-Alder mechanism. A gene cluster, including a putative sesquiterpene 1-11 cyclase, was identified through phylogenetic and RNA-seq analysis, and is proposed to be responsible for the biosynthesis of 1 and 2.

Indexed as

Metabolic Networks and PathwaysAgaricalesBasidiomycotaBiological ProductsFiltrationMagnetic Resonance SpectroscopyMolecular StructureSesquiterpenesBiological ProductsSesquiterpenes

Identifiers

PMID32251434
PMCPMC7135263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.