ArticleNature structural & molecular biology2020
Structural and functional characterization of the bestrophin-2 anion channel.
Open access · greenAbstract read
In one paragraph
Article in Nature structural & molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- From BEST1 mutations to retinal regeneration: integrating stem cell-derived RPE models and gene correction strategies.Frontiers in cell and developmental biology · 2026Review
- Cryo-EM structures of mouse bestrophin 1 channel in closed and partially open conformations.Molecules and cells · 2025Article
- The pentameric chloride channel BEST1 is activated by extracellular GABA.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Electronic Polarizability Tunes the Function of the Human Bestrophin 1 ClJournal of chemical theory and computation · 2025Article
- Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment.Nature communications · 2024Article
- GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel.Nature communications · 2024Article
- Electronic Polarizability Tunes the Function of the Human Bestrophin 1 ClbioRxiv : the preprint server for biology · 2024Article
- Chromosome-scale assembly of the streamlined picoeukaryoteMicrobial genomics · 2024Article
- Computational Investigation of Mechanisms for pH Modulation of Human Chloride Channels.Molecules (Basel, Switzerland) · 2023Article
- Role of surfactants in electron cryo-microscopy film preparation.Biophysical journal · 2023Article
- Cytosolic domain regulates the calcium sensitivity and surface expression of BEST1 channels in the HEK293 cells.BMB reports · 2023Article
- Article
- [Research advances on the regulatory mechanism of sweat secretion ion channels of eccrine sweat glands].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- Structures and gating mechanisms of human bestrophin anion channels.Nature communications · 2022Article
- Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels.Nature structural & molecular biology · 2022Article
- Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1.Nature communications · 2022Article
- Developing Graphene Grids for Cryoelectron Microscopy.Frontiers in molecular biosciences · 2022Review
- Structure and Function of the Bestrophin family of calcium-activated chloride channels.Channels (Austin, Tex.) · 2021Review
- Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis.Communications biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Aaron P Owji *Department of Pharmacology, Columbia University, New York, NY, USA.
Qingqing Zhao *Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Changyi JiDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Alec KittredgeDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Austin HopiavuoriDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Ziao FuDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Nancy WardDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Oliver B ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Yin ShenEye Center, Renmin Hospital of Wuhan University, Wuhan, China. yinshen@whu.edu.cn.ORCID http://orcid.org/0000-0002-4201-3948
Yu ZhangDepartment of Ophthalmology, Columbia University, New York, NY, USA. yz3802@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-6525-2458
Wayne A HendricksonDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. wah2@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-1412-5747
Tingting YangDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA. ty2190@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-5220-588X
University of Rochester · USColumbia University · USColumbia University Irving Medical Center · USWuhan University · CN
Funding
ZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI SCOTT, EMILY E · 1985 to 2011
$38.9MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI KIEFT, JEFFREY S · 2012 to 2021
$14.7MTraining (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1MProposal for an Administrative Supplement for Equipment Purchases for NIGMS Awardees NOT-GM-18-022R01GM107462 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENDRICKSON, WAYNE A. · 2014 to 2021
$3.6MMechanistic Characterization of Calcium-Activated Chloride Channels in Retinal Pigment EpitheliumR01GM127652 · NIGMS · UNIVERSITY OF ROCHESTER · PI YANG, TINGTING · 2018 to 2022
$1.7MStructure-function Analysis of BestrophinsR00EY025290 · NEI · UNIVERSITY OF ROCHESTER · PI YANG, TINGTING · 2016 to 2018
$747kStructural analysis of the bestrophin anion channel Best2F31EY030763 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWJI, AARON PAUL · 2019 to 2021
$137kStructure-function Analysis of BestrophinsK99EY025290 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YANG, TINGTING · 2015 to 2015
$106kNCRR NIH HHS P41 RR001209NEI NIH HHS F31 EY030763NEI NIH HHS K99 EY025290NEI NIH HHS R00 EY025290NIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R01 GM107462NIGMS NIH HHS R01 GM127652
Abstract
The bestrophin family of calcium (Ca
Indexed as
Protein ConformationAnimalsBestrophinsCalciumCattleChloride ChannelsCryoelectron MicroscopyCytoplasmHumansIon Channel GatingProtein BindingSignal TransductionBEST1 protein, humanBestrophinsCalciumChloride Channels
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.