Evidence map›Paper›PMID 32251392›Full record

ReviewNature biomedical engineering2020

Engineered reproductive tissues.

Emma S Gargus, Hunter B Rogers, Kelly E McKinnon, Maxwell E Edmonds, Teresa K Woodruff

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Synthetic embryos: current progress, application and challenges.Reproductive biology and endocrinology : RB&E · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
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  17. Review
  18. Review
  19. Tailor-made 3DFrontiers in endocrinology · 2025
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Emma S Gargus *Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Hunter B Rogers *Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kelly E McKinnon *Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Maxwell E Edmonds *Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Teresa K WoodruffDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. tkw@northwestern.edu.ORCID http://orcid.org/0000-0002-1197-3399
Northwestern University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Medical Scientist Training ProgramT32GM144295 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2022 to 2026
$9.1M
Ex Vivo Female Reproductive Tract Integration In a 3D Microphysiologic SystemUH3TR001207 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOODRUFF, TERESA K · 2014 to 2016
$4.9M
PCOS and androgen-related disease modeling and drug testing in Multi-organ Integrated Microfluidic Reproductive PlatformUH3ES029073 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIM, JI-YONG JULIE · 2019 to 2021
$3.6M
PCOS and androgen-related disease modeling and drug testing in Multi-organ Integrated Microfluidic Reproductive PlatformUG3ES029073 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOODRUFF, TERESA K · 2017 to 2018
$3.0M
Modeling ovarian aging phenotype in mechanically tuned 3D matricesF30AG058387 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GARGUS, EMMA · 2018 to 2021
$155k
Assessing microenvironment and endothelial cell instruction of testis functionF31HD089693 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI EDMONDS, MAXWELL ETHAN · 2017 to 2019
$149k
NCATS NIH HHS UH3 TR001207NIA NIH HHS F30 AG058387NICHD NIH HHS F31 HD089693NIEHS NIH HHS UG3 ES029073NIEHS NIH HHS UH3 ES029073NIGMS NIH HHS T32 GM008152NIGMS NIH HHS T32 GM144295
6 · The paper itself

Abstract

Engineered male and female biomimetic reproductive tissues are being developed as autonomous in vitro units or as integrated multi-organ in vitro systems to support germ cell and embryo function, and to display characteristic endocrine phenotypic patterns, such as the 28-day human ovulatory cycle. In this Review, we summarize how engineered reproductive tissues facilitate research in reproductive biology, and overview strategies for making engineered reproductive tissues that might eventually allow the restoration of reproductive capacity in patients.

Indexed as

Genitalia, FemaleGenitalia, MaleReproductionTissue EngineeringBiocompatible MaterialsBioprintingCell EncapsulationFemaleGerm CellsHumansHydrogelsMaleMicrofluidicsPrinting, Three-DimensionalTestisTissue ScaffoldsBiocompatible MaterialsHydrogels

Identifiers

PMID32251392
PMCPMC7416444
OpenAlexW3014297870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.