ArticleScientific reports2020
Combined transcriptomic and metabolomic analyses uncover rearranged gene expression and metabolite metabolism in tobacco during cold acclimation.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 78 citations in OpenAlex.
- Analysis of the effect of variable frequency fan on tobacco metabolites during curing via untargeted metabolomics.BMC plant biology · 2026Article
- Metabolic engineering for tobacco quality improvement: Advances and perspectives.Metabolic engineering communications · 2026Review
- Responses and adaptations of plants to abiotic stress: transcriptional regulation of secondary metabolic pathways, metabolomics, and nanobiological approaches.Frontiers in genetics · 2026Review
- Plant responses to cold stress: molecular and physiological adaptive mechanisms with breeding advances.Frontiers in plant science · 2026Review
- Dynamic transcriptomic and metabolomic adaptation mechanisms of Trifolium ambiguum under different durations of cold stress.Scientific reports · 2025Article
- Integrated analysis of transcriptomic and metabolomic reveal insights into low-temperature stress in sainfoin (Onobrychis viciifolia) seedlings.BMC plant biology · 2025Article
- A Study on the Application of COFoods (Basel, Switzerland) · 2025Article
- Climate-Resilient Crops: Integrating AI, Multi-Omics, and Advanced Phenotyping to Address Global Agricultural and Societal Challenges.Plants (Basel, Switzerland) · 2025Review
- Progress in Transcriptomics and Metabolomics in Plant Responses to Abiotic Stresses.Current issues in molecular biology · 2025Review
- Transcriptomic and metabolomic analysis reveal the cold tolerance mechanism of common beans under cold stress.BMC plant biology · 2025Article
- Cold stress adaptation inFrontiers in plant science · 2025Article
- Multiomic analysis of the synthetic pathways of secondary metabolites in tobacco leaves at different developmental stages.Frontiers in plant science · 2025Article
- Multi-Omics Analysis Provides Insights into Green Soybean in Response to Cold Stress.Metabolites · 2024Article
- A Multi-Omics View of Maize's (International journal of molecular sciences · 2024Article
- A novel AP2/ERF transcription factor, NtERF10, positively regulates plant height in tobacco.Transgenic research · 2024Article
- Integrated transcriptomic and metabolomic analysis provides insights into cold tolerance in lettuce (Lactuca sativa L.).BMC plant biology · 2024Article
- Transcriptome Analysis Reveals POD as an Important Indicator for Assessing Low-Temperature Tolerance in Maize Radicles during Germination.Plants (Basel, Switzerland) · 2024Article
- Study on peanut protein oxidation and metabolomics/proteomics analysis of peanut response under hypoxic/re-aeration storage.Food chemistry: X · 2024Article
- Integrated transcriptomic and metabolomic data reveal the cold stress responses molecular mechanisms of two coconut varieties.Frontiers in plant science · 2024Article
- Genome-Wide Analysis ofPlants (Basel, Switzerland) · 2023Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cold temperatures often severely restrict the growth, distribution and productivity of plants. The freezing tolerance of plants from temperate climates can be improved by undergoing periods of cold acclimation (CA). Tobacco is an important economic plant and is sensitive to cold stress. However, the dynamic changes and regulatory mechanisms of gene expression and metabolic processes during CA remain largely unknown. In this study, we performed RNA sequencing and metabolomic profiling analyses to identify the genes and metabolites specifically expressed during CA. Our transcriptomic data revealed 6905 differentially expressed genes (DEGs) during CA. Functional annotation and enrichment analyses revealed that the DEGs were involved mainly in signal transduction, carbohydrate metabolism and phenylpropanoid biosynthesis. Moreover, a total of 35 significantly changed metabolites were identified during CA via an LC-MS platform. Many protective metabolites, such as amino acids, carbohydrates, tricarboxylic acid (TCA) cycle intermediates and phenylpropanoid-related substances, were identified during CA. The gene-metabolite network extensively outlined the biological processes associated with the utilization of sugars, activation of amino acid metabolism, TCA cycle and phenylpropanoid biosynthesis in tobacco under CA. The results of our present study provide a comprehensive view of signal transduction and regulation, gene expression and dynamic changes in metabolites during CA.
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