ArticleeLife2020
Nicotinamide mononucleotide adenylyltransferase uses its NAD
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Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Nicotinamide Mononucleotide Adenylyltransferase 1 and NADMetabolites · 2026Review
- The nicotinamide mononucleotide adenylyl transferase (NMNAT/Nma1) modulates phosphate-sensing (PHO) signaling independent of its NAD+ synthesis activity in Saccharomyces cerevisiae.FEMS yeast research · 2026Article
- Mitochondrial NMNAT3 reduces amyloid aggregates inMitochondrial communications · 2026Article
- Unveiling a novel broad-host-range cyanomyovirus cross-infecting Prochlorococcus and Synechococcus.BMC biology · 2025Article
- The Roles of Moonlighting Nicotinamide Mononucleotide Adenylyl Transferases in Cell Physiology.International journal of molecular sciences · 2025Review
- Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells.Biomolecules · 2024Review
- Regulation of proteostasis by sleep through autophagy inLife science alliance · 2024Article
- Nicotinamide Adenine Dinucleotide (NADAntioxidants & redox signaling · 2023Review
- Tau-mediated axonal degeneration is prevented by activation of the WldBrain communications · 2023Article
- Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology.eLife · 2022Article
- The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions.IUBMB life · 2022Review
- The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins.The Journal of biological chemistry · 2022Article
- Human Nmnat1 Promotes Autophagic Clearance of Amyloid Plaques in aFrontiers in aging neuroscience · 2022Article
- The expanding field of non-canonical RNA capping: new enzymes and mechanisms.Royal Society open science · 2021Review
- Review
- NADSignal transduction and targeted therapy · 2020Review
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 2 countries.
Xiaojuan Ma *Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-2682-0501
Yi Zhu *Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, United States.ORCID 0000-0002-1778-8880
Jinxia LuBio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jingfei XieInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Chong LiDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, United States.
Woo Shik ShinDepartment of Neurology, Molecular Biology Institute, and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.
Jiali QiangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Jiaqi LiuSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.
Shuai DouInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Yi XiaoInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Chuchu WangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-2015-7331
Chunyu JiaInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Houfang LongInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Juntao YangState Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yanshan FangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-4123-0174
Lin JiangDepartment of Neurology, Molecular Biology Institute, and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0003-3039-1877
Yaoyang ZhangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Shengnan ZhangInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Rong Grace ZhaiDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, United States.ORCID 0000-0002-7599-1430
Cong LiuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-3425-6672
Dan LiBio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-1609-1539
Chinese Academy of Sciences · CNUniversity of Miami · USShanghai Jiao Tong University · CNUniversity of California, Los Angeles · USChinese Academy of Medical Sciences & Peking Union Medical College · CNYantai University · CN
Funding
microRNA regulation of NMNAT-mediated Neuroprotection against Peripheral Neuropathy and Chronic PainR61AT010408 · NCCIH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZHAI, RONG GRACE · 2019 to 2020
$880kEnhance Neuroprotection through post-transcriptional regulationsR56NS095893 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZHAI, RONG GRACE · 2017 to 2017
$384kMajor State Basic Research Development Program 2016YFA0501902National Natural Science Foundation of China 91853113NCCIH NIH HHS R61 AT010408NINDS NIH HHS R56 NS095893Shanghai Municipal Education Commission 2019-01-07-00-02-E00037Shanghai Municipal Science and Technology Major Project 2019SHZDZX02Shanghai Pujiang Program 18PJ1404300
Abstract
Tau hyper-phosphorylation and deposition into neurofibrillary tangles have been found in brains of patients with Alzheimer's disease (AD) and other tauopathies. Molecular chaperones are involved in regulating the pathological aggregation of phosphorylated Tau (pTau) and modulating disease progression. Here, we report that nicotinamide mononucleotide adenylyltransferase (NMNAT), a well-known NAD
Indexed as
AnimalsBinding SitesDrosophilaHomeostasisHSP90 Heat-Shock ProteinsHumansMolecular ChaperonesNADNicotinamide-Nucleotide AdenylyltransferasePhosphorylationSynapsestau ProteinsHSP90 Heat-Shock ProteinsMolecular ChaperonesNADNicotinamide-Nucleotide Adenylyltransferasetau ProteinsAlzheimer's diseasebiochemistrychaperonechemical biologyD. melanogasterNAD synthaseNMNATphosphorylated Tautauopathy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.