Evidence map›Paper›PMID 32250724›Full record

ReviewAnnual review of neuroscience2020

Neuromodulation of Brain State and Behavior.

David A McCormick, Dennis B Nestvogel, Biyu J He

Abstract readReview
In one paragraph

Review in Annual review of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed.

  1. Article
  2. Article
  3. Neural and autonomic predictors of future listening errors.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Protecting episodic memory after sleep loss: Similar benefits of exercise and naps via distinct neural contributions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Review
  8. Auditory Cortex Distinguishes between Spontaneous and Sound-Evoked Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  9. Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026
    Article
  10. The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026
    Article
  11. A single brief cue leaves a day-long internal state imprint in planarians.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David A McCormickInstitute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA; email: davidmc@uoregon.edu.
Dennis B NestvogelInstitute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA; email: davidmc@uoregon.edu.
Biyu J HeDepartments of Neurology, Neuroscience and Physiology, and Radiology, Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.

Funding

Cortical Dynamics and Neural/Behavioral PerformanceR35NS097287 · NINDS · YALE UNIVERSITY · PI MCCORMICK, DAVID · 2017 to 2024
$6.1M
Mechanisms of Rapid Modulation of Auditory ResponsivenessR01DC015803 · NIDCD · YALE UNIVERSITY · PI MCCORMICK, DAVID · 2017 to 2021
$1.6M
NIDCD NIH HHS R01 DC015803NINDS NIH HHS R35 NS097287
6 · The paper itself

Abstract

Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans and animals reveal that these variations are not random in their nature, but may in fact be due in large part to rapid shifts in neural, cognitive, and behavioral states. Here we review recent advances in the understanding of rapid variations in the waking state, how variations are generated, and how they modulate neural and behavioral responses in both mice and humans. We propose that the brain has an identifiable set of states through which it wanders continuously in a nonrandom fashion, owing to the activity of both ascending modulatory and fast-acting corticocortical and subcortical-cortical neural pathways. These state variations provide the backdrop upon which the brain operates, and understanding them is critical to making progress in revealing the neural mechanisms underlying cognition and behavior.

Indexed as

AnimalsBehaviorBrainCerebral CortexHumansNerve NetNeural PathwaysNeuronscerebral cortexhumanperceptionperformancespontaneous activityvariability

Identifiers

PMID32250724
PMCPMC12237593

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.