ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020
Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications.Biomedicines · 2025Review
- Synthesis and Anticancer Activity Assessment of Zelkovamycin Analogues.Molecules (Basel, Switzerland) · 2024Article
- Actinomadura graeca sp. nov.: A novel producer of the macrocyclic antibiotic zelkovamycin.PloS one · 2021Article
- Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Natural products (NPs) are an important inspirational source for developing drugs and chemical probes. In 1999, the group of Ōmura reported the constitutional elucidation of zelkovamycin. Although largely unrecognized so far, this NP displays structural similarities as well as differences to the argyrin NP family, a class of peptidic NPs with promising anticancer activities and diverse mode-of-action at the molecular level. By a combination of structure elucidation experiments, the first total synthesis of zelkovamycin and bioassays, the zelkovamycin configuration was determined and its previously proposed molecular structure was revised. The full structure assignment proves zelkovamycin as an additional member of the argyrins with however unique OXPHOS inhibitory properties. Zelkovamycin may therefore not only serve as a new starting point for chemical inhibitors of the OXPHOS system, but also guide customized argyrin NP isolation and biosynthesis studies.
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Registered trials
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