ArticleBritish journal of clinical pharmacology2020
Differential effects of antidepressant subgroups on risk of acute myocardial infarction: A nested case-control study.
Article in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- The cardiovascular safety of tricyclic antidepressants in overdose and in clinical use.Therapeutic advances in psychopharmacology · 2024Review
- Serotonin-Affecting Antidepressant Use in Relation to Platelet Reactivity.Clinical pharmacology and therapeutics · 2022Article
- Differential effects of antidepressant subgroups on risk of acute myocardial infarction: A nested case-control study.British journal of clinical pharmacology · 2020Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The primary objective of this study was to investigate the association between antidepressants use and the risk of acute myocardial infarction (AMI).
methodsWe conducted a nested case-control study using a primary care database over the period 2002-2015. From a cohort of patients aged 40-99 years, we identified incident AMI cases and randomly selected 5 controls per case, matched to cases for exact age, sex and index date. Exposure to antidepressants were categorised as current, recent, past and nonusers. Adjusted odds ratio (AOR) and 95% confidence interval (CI) were computed using conditional logistic regression to assess the association between the current use of different antidepressants subgroups and AMI as compared to nonuse. Dose and duration effects were explored.
resultsTotals of 24 155 incident AMI cases and 120 775 controls were included. The current use of antidepressants as a group was associated with a reduced risk (AOR = 0.86; 95% CI: 0.81-0.91), but mainly driven by selective serotonin reuptake inhibitors (AOR = 0.86; 95% CI:0.81-0.93). A reduced risk was also observed with trazodone (AOR = 0.76;95% CI: 0.64-0.91), and clomipramine (AOR = 0.62; 95% CI: 0.40-0.96), whereas no significant effect was observed with other antidepressants. A duration-dependent effect was suggested for selective serotonin reuptake inhibitors, trazodone and clomipramine, while there was no clear dose-dependency.
conclusionThis study suggests that current use of antidepressants interfering selectively with the reuptake of serotonin, and those antagonizing the 5-HT
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