Evidence map›Paper›PMID 32250318›Full record

ArticleJournal of Parkinson's disease2020

Plasma Metabolomic Markers of Insulin Resistance and Diabetes and Rate of Incident Parkinson's Disease.

Samantha Molsberry, Kjetil Bjornevik, Katherine C Hughes, Zhongli Joel Zhang, Sarah Jeanfavre, Clary Clish, Brian Healy, Michael Schwarzschild, Alberto Ascherio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Samantha MolsberryPopulation Health Sciences Program, Harvard University, Cambridge, MA, USA.
Kjetil BjornevikDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Katherine C HughesDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Zhongli Joel ZhangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sarah JeanfavreMetabolomics Platform, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Clary ClishMetabolomics Platform, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Brian HealyPartners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA.
Michael SchwarzschildDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Alberto AscherioDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Harvard University · USMassachusetts Institute of Technology · USBrigham and Women's Hospital · USMassachusetts General Hospital · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Metabolomics and risk of Parkinson's DiseaseR01NS089619 · NINDS · HARVARD SCHOOL OF PUBLIC HEALTH · PI ASCHERIO, ALBERTO · 2015 to 2019
$3.3M
NCI NIH HHS R01 CA049449NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NIDDK NIH HHS P30 DK040561NINDS NIH HHS R01 NS089619
6 · The paper itself

Abstract

backgroundAlthough there is evidence of shared dysregulated pathways between diabetes and Parkinson's disease, epidemiologic research on an association between the two diseases has produced inconsistent results.

objectiveWe aimed to assess whether known metabolomic markers of insulin resistance and diabetes are also associated with Parkinson's disease development.

methodsWe conducted a nested case-control study among Nurses' Health Study and Health Professionals Follow-up Study participants who had provided blood samples up to twenty years prior to Parkinson's diagnosis. Cases were matched to risk-set sampled controls by age, sex, fasting status, and time of blood collection. Participants provided covariate information via regularly collected cohort questionnaires. We used conditional logistic regression models to assess whether plasma levels of branched chain amino acids, acylcarnitines, glutamate, or glutamine were associated with incident development of Parkinson's disease.

resultsA total of 349 case-control pairs were included in this analysis. In the primary analyses, none of the metabolites of interest were associated with Parkinson's disease development. In investigations of the association between each metabolite and Parkinson's disease at different time intervals prior to diagnosis, some metabolites showed marginally significant association but, after correction for multiple testing, only C18 : 2 acylcarnitine was significantly associated with Parkinson's disease among subjects for whom blood was collected less than 60 months prior to case diagnosis.

conclusionsPlasma levels of diabetes-related metabolites did not contribute to predict risk of Parkinson's disease. Further investigation of the relationship between pre-diagnostic levels of diabetes-related metabolites and Parkinson's disease in other populations is needed to confirm these findings.

Indexed as

AdultAgedBiomarkersCarnitineDiabetes MellitusFemaleHumansInsulin ResistanceMaleMetabolomicsMiddle AgedParkinson DiseasePlasmaRisk FactorsacylcarnitineBiomarkersCarnitinediabetes mellitusepidemiologymetabolomicsParkinson’s disease

Identifiers

PMID32250318
PMCPMC8034435
OpenAlexW3014155628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.