ArticleAngewandte Chemie (International ed. in English)2020
Ligand-Enabled γ-C(sp
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 78 citations in OpenAlex.
- Transition Metal-Catalyzed Direct C(spChemical reviews · 2026Review
- Regiocontrollable [2 + 2] benzannulation of γ,δ-C(sp3)-H bonds with dihaloarenes using palladium catalysis.Nature synthesis · 2025Article
- Catalyst-Controlled Chemoselective γ-C(spJournal of the American Chemical Society · 2024Article
- Versatile Copper-Catalyzed γ-C(spJournal of the American Chemical Society · 2024Article
- Tandem dehydrogenation-olefination-decarboxylation of cycloalkyl carboxylic acids via multifold C-H activation.Nature communications · 2024Article
- Ligand-Enabled Double γ-C(spAngewandte Chemie (International ed. in English) · 2023Article
- Access to unsaturated bicyclic lactones by overriding conventional C(spNature chemistry · 2023Article
- Multiple remote C(spChemical science · 2022Article
- Catalyst-controlled site-selective methylene C-H lactonization of dicarboxylic acids.Science (New York, N.Y.) · 2022Article
- PdJournal of the American Chemical Society · 2022Article
- Pd-catalysed C-H functionalisation of free carboxylic acids.Chemical science · 2022Review
- Transition-Metal-Catalyzed Annulations Involving the Activation of C(spAngewandte Chemie (International ed. in English) · 2022Review
- Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(spChemical reviews · 2021Review
- Hexafluoroisopropanol: the magical solvent for Pd-catalyzed C-H activation.Chemical science · 2021Review
- Recent development in transition metal-catalysed C-H olefination.Chemical science · 2021Review
- Tailored quinones support high-turnover Pd catalysts for oxidative C-H arylation with OScience (New York, N.Y.) · 2020Article
- Direct β- and γ-C(spAngewandte Chemie (International ed. in English) · 2020Article
- Nickel-catalyzed reductive coupling of homoenolates and their higher homologues with unactivated alkyl bromides.Nature communications · 2020Article
- Diverse strategies for transition metal catalyzed distal C(spChemical science · 2020Review
- A direct route to six and seven membered lactonesChemical science · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the ligand-enabled C-H activation/olefination of free carboxylic acids in the γ-position. Through an intramolecular Michael addition, δ-lactones are obtained as products. Two distinct ligand classes are identified that enable the challenging palladium-catalyzed activation of free carboxylic acids in the γ-position. The developed protocol features a wide range of acid substrates and olefin reaction partners and is shown to be applicable on a preparatively useful scale. Insights into the underlying reaction mechanism obtained through kinetic studies are reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.