ArticleHuman brain mapping2020
Cerebellar-cortical dysconnectivity in resting-state associated with sensorimotor tasks in schizophrenia.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals.Cerebellum (London, England) · 2024Pooled it
- Digitalized transcranial electrical stimulation: A consensus statement.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Pooled it
- Cerebellar gray matter volume changes in patients with schizophrenia: A voxel-based meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.Brain : a journal of neurology · 2026Review
- The cerebro-cerebellar system: Integrative roles in motor control, cognition, and neuropsychiatric disorders.IBRO neuroscience reports · 2026Review
- Cerebellar gray matter volume difference in first-episode bipolar and unipolar depression.BMC psychiatry · 2026Article
- Microstructural Alterations of the Cerebellum-Ventral Tegmental Area Pathways in First-Episode Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- NeuroMark-DyFICA: NeuroMark dynamic frequency-informed ICA with high-frequency spatial filtering for windowed fMRI analysis.Network neuroscience (Cambridge, Mass.) · 2026Article
- Cerebellar structure is abnormal in schizophrenia and deviates from bipolar disorder.NeuroImage. Clinical · 2026Article
- st-DenseViT: A Weakly Supervised Spatiotemporal Vision Transformer for Dense Prediction of Dynamic Brain Networks.Human brain mapping · 2025Article
- aNy-way ICA and its application to estimate cortico-thalamo-cerebellar functional links in schizophrenia.bioRxiv : the preprint server for biology · 2025Article
- Reduced finger tapping speed in patients with schizophrenia and psychomotor slowing: an exploratory fMRI study.Frontiers in psychiatry · 2025Article
- Psychomotor slowing in schizophrenia is associated with aberrant postural control.Schizophrenia (Heidelberg, Germany) · 2024Article
- Isolation of Distinct Networks Driving Action and Cognition in Psychomotor Processes.Biological psychiatry · 2024Article
- Altered functional connectivity of cerebellar subregions in male patients with obstructive sleep apnea: A resting-state fMRI study.Neuroradiology · 2024Article
- Altered spontaneous regional brain activity in ventromedial prefrontal cortex and visual area of expert table tennis athletes.Brain imaging and behavior · 2024Article
- Functional Connectivity Differences in Distinct Dentato-Cortical Networks in Alzheimer's Disease and Mild Cognitive Impairment.bioRxiv : the preprint server for biology · 2024Article
- Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions.Aging and disease · 2024Review
- Shared and Disorder-Specific Alterations of Brain Temporal Dynamics in Obsessive-Compulsive Disorder and Schizophrenia.Schizophrenia bulletin · 2023Article
- Cerebellar Structure and Cognitive Ability in Psychosis.Biological psychiatry · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Abnormalities of cerebellar function have been implicated in the pathophysiology of schizophrenia. Since the cerebellum has afferent and efferent projections to diverse brain regions, abnormalities in cerebellar lobules could affect functional connectivity with multiple functional systems in the brain. Prior studies, however, have not examined the relationship of individual cerebellar lobules with motor and nonmotor resting-state functional networks. We evaluated these relationships using resting-state fMRI in 30 patients with a schizophrenia-spectrum disorder and 37 healthy comparison participants. For connectivity analyses, the cerebellum was parcellated into 18 lobular and vermal regions, and functional connectivity of each lobule to 10 major functional networks in the cerebrum was evaluated. The relationship between functional connectivity measures and behavioral performance on sensorimotor tasks (i.e., finger-tapping and postural sway) was also examined. We found cerebellar-cortical hyperconnectivity in schizophrenia, which was predominantly associated with Crus I, Crus II, lobule IX, and lobule X. Specifically, abnormal cerebellar connectivity was found to the cerebral ventral attention, motor, and auditory networks. This cerebellar-cortical connectivity in the resting-state was differentially associated with sensorimotor task-based behavioral measures in schizophrenia and healthy comparison participants-that is, dissociation with motor network and association with nonmotor network in schizophrenia. These findings suggest that functional association between individual cerebellar lobules and the ventral attentional, motor, and auditory networks is particularly affected in schizophrenia. They are also consistent with dysconnectivity models of schizophrenia suggesting cerebellar contributions to a broad range of sensorimotor and cognitive operations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.