Evidence map›Paper›PMID 32250004›Full record

ArticleMacromolecular rapid communications2020

pH-Responsive Polymers for Improving the Signal-to-Noise Ratio of Hypoxia PET Imaging with [

Jeroen A C M Goos, Maria Davydova, Nigel Lengkeek, Ivan Greguric, Michael R Whittaker, John F Quinn, Jonathan B Baell, Jason S Lewis, Thomas P Davis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular rapid communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. [Molecules (Basel, Switzerland) · 2024
    Review
  3. Review
  4. Nanoscale Radiotheranostics for Cancer Treatment: From Bench to Bedside.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Jeroen A C M GoosDepartment of Clinical Neuroscience and MedTechLabs, Karolinska Institute, Solna, 17177, Sweden.ORCID https://orcid.org/0000-0003-2010-7377
Maria DavydovaDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
Nigel LengkeekAustralian Nuclear Science and Technology Organisation, Lucas Heights, NSW, 2234, Australia.
Ivan GreguricAustralian Nuclear Science and Technology Organisation, Lucas Heights, NSW, 2234, Australia.
Michael R WhittakerDepartment of Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia.
John F QuinnDepartment of Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia.
Jonathan B BaellDepartment of Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia.
Jason S LewisDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.ORCID https://orcid.org/0000-0001-7065-4534
Thomas P DavisDepartment of Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia.ORCID https://orcid.org/0000-0003-2581-4986
Systems Dynamics (United States) · USAustralian Nuclear Science and Technology Organisation · AUMemorial Sloan Kettering Cancer Center · USKarolinska Institutet · SEParks Victoria · AU

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology CE140100036NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA232130NIH HHS P30 CA008748-48NIH HHS R35 CA232130
6 · The paper itself

Abstract

To improve the signal-to-noise ratio of hypoxia positron emission tomography (PET) imaging, stimuli-responsive polymers are designed for the delivery of the hypoxia PET tracer fluorine-18 labeled fluoromisonidazole ([

Indexed as

HypoxiaPositron-Emission TomographyFluorine RadioisotopesHumansHydrogen-Ion ConcentrationMisonidazoleMolecular StructureSignal-To-Noise RatioFluorine-18Fluorine RadioisotopesfluoromisonidazoleMisonidazolefluoromisonidazolehypoxiapolymersstimuli-responsive materials

Identifiers

PMID32250004
PMCPMC8339940
OpenAlexW3014684928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.