Evidence map›Paper›PMID 32249998›Full record

ArticleNeurourology and urodynamics2020

Prevalence, subtypes, and correlates of nocturia in the symptoms of Lower Urinary Tract Dysfunction Research Network cohort.

J Quentin Clemens, Jonathan B Wiseman, Abigail R Smith, Cindy L Amundsen, Claire C Yang, Megan S Bradley, Ziya Kirkali, Nnenaya Q Agochukwu, Anne P Cameron, LURN Study Group

Open access · greenAbstract read
In one paragraph

Article in Neurourology and urodynamics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

J Quentin ClemensDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Jonathan B WisemanArbor Research Collaborative for Health, Ann Arbor, Michigan.
Abigail R SmithArbor Research Collaborative for Health, Ann Arbor, Michigan.
Cindy L AmundsenDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
Claire C YangDepartment of Urology, University of Washington, Seattle, Washington.
Megan S BradleyDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.ORCID 0000-0001-9935-5132
Ziya KirkaliNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Nnenaya Q AgochukwuDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Anne P CameronDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
LURN Study Group
University of Michigan · USArbor Research Collaborative for Health · USDuke University · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Washington · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating CenterU24DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI GRAFF, JOHN JOSEPH · 2019 to 2025
$6.9M
Phenotype of urinary symptoms and relationships with genotype, sleep and obesityU01DK097779 · NIDDK · UNIVERSITY OF CHICAGO · PI GRIFFITH, JAMES WILLIAM, KENTON, KIMBERLY SUE · 2012 to 2025
$5.7M
Advancing the Measurement and Classification of Lower Urinary Tract DysfunctionU01DK097780 · NIDDK · DUKE UNIVERSITY · PI AMUNDSEN, CINDY, JELOVSEK, JOHN ERIC · 2012 to 2025
$5.3M
University of Iowa LURN Research SiteU01DK097772 · NIDDK · UNIVERSITY OF IOWA · PI BRADLEY, CATHERINE S, KREDER, KARL J · 2012 to 2025
$5.0M
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)U01DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI MERION, ROBERT M · 2013 to 2018
$4.6M
University of Washington LURN Research SiteU01DK100011 · NIDDK · UNIVERSITY OF WASHINGTON · PI YANG, CLAIRE C · 2013 to 2025
$4.5M
University of Michigan LURN Research SiteU01DK099932 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN · 2013 to 2023
$4.4M
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Second Phase StudyU01DK100017 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2013 to 2025
$3.9M
University of Michigan UroEPI Career Development ProgramK12DK111011 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN, SARMA, ARUNA V · 2016 to 2025
$3.6M
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)Data CoordinatU01DK097776 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI MERION, ROBERT M · 2012 to 2016
$1.7M
NCATS NIH HHS UL1 TR001422NIDDK NIH HHS K12 DK111011NIDDK NIH HHS U01 DK097772NIDDK NIH HHS U01 DK097776NIDDK NIH HHS U01 DK097779NIDDK NIH HHS U01 DK097780NIDDK NIH HHS U01 DK099879NIDDK NIH HHS U01 DK099932NIDDK NIH HHS U01 DK100011NIDDK NIH HHS U01 DK100017NIDDK NIH HHS U24 DK099879
6 · The paper itself

Abstract

aimsWe determined the prevalence, severity, and correlates of nocturia in a large clinical cohort of patients.

methodsPatients presenting with lower urinary tract symptoms (LUTS) completed 3-day bladder diaries. Nocturia was quantified based on the mean number of nighttime voids documented over the 3 days. Nocturia subtypes (global polyuria, nocturnal polyuria [NP], reduced global bladder capacity, and reduced nocturnal bladder capacity) were assessed. Bother due to nocturia was measured by the LUTS Tool. Sleep quality was assessed with the Patient-Reported Outcomes Measurement Information System Sleep Scale. Multivariable multinomial regression was used to explore patient characteristics associated with nocturia.

resultsIn 502 participants with analyzable diaries (285 men and 217 women), the mean number of nocturia episodes over 3 days was 0 in 103 (20.5%), >0 to <1 in 151 (20.1%), 1 to <2 in 165 (32.9%), and ≥2 in 83 (16.5%). Sixty-seven percent of the participants with nocturia ≥1 reported significant bother from their nocturia. NP was the most common nocturia subtype and was present in 17% of those with nocturia = 0, 40% of those with nocturia >0 to <1, 65% of those with nocturia 1 to <2%, and 77% with nocturia 2+. Higher degrees of nocturia were associated with male sex, greater sleep disturbance, and a higher likelihood of exhibiting multiple nocturia subtypes.

conclusionsNocturia ≥1 occurred in 49% of LUTS patients and caused significant bother in the majority of them. The most common subtype was NP, but a substantial proportion of patients exhibited additional characteristics.

Indexed as

AdultAgedFemaleHumansLower Urinary Tract SymptomsMaleMiddle AgedNocturiaPolyuriaPrevalenceUrinary Bladderbladder diarybothernocturnal polyuriasleepvoiding diary

Identifiers

PMID32249998
PMCPMC7238757
OpenAlexW3014268491

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.