Evidence map›Paper›PMID 32249967›Full record

ArticlePaediatric and perinatal epidemiology2020

Pregnancy intention and phthalate metabolites among pregnant women in The Infant Development and Environment Study cohort.

Grace R Lyden, Emily S Barrett, Sheela Sathyanarayana, Nicole R Bush, Shanna H Swan, Ruby H N Nguyen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric and perinatal epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Grace R LydenDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, USA.ORCID 0000-0003-1408-851X
Emily S BarrettDepartment of Epidemiology and Biostatistics, Rutgers School of Public Health, Piscataway, NJ, USA.
Sheela SathyanarayanaDepartment of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA, USA.
Nicole R BushDepartments of Psychiatry and Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Shanna H SwanDivision of Preventive Medicine and Community Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ruby H N NguyenDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.ORCID 0000-0002-6598-8457

Funding

TIDES III: Endocrine Disruption, Hormones, and Sex Differences in Adolescent Airway HealthR01ES025169 · NIEHS · SEATTLE CHILDREN'S HOSPITAL · PI Sheela Sathyanarayana · 2015 to 2026
$9.5M
The Infant Development and the Environmental Study (TIDES)R01ES016863 · NIEHS · UNIVERSITY OF ROCHESTER · PI SWAN, SHANNA H · 2009 to 2014
$4.0M
Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stressZIAES103313 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FERGUSON, KELLY · 2016 to 2022
$1.9M
Intramural NIH HHS ZIA ES103313NIEHS NIH HHS R01 ES016863NIEHS NIH HHS R01 ES016863-02S4NIEHS NIH HHS R01 ES016863-04NIEHS NIH HHS R01 ES025169
6 · The paper itself

Abstract

backgroundPreconception life style and health play a pivotal role in positively impacting the health of a pregnancy, and this includes the reduction of exposure to endocrine-disrupting chemicals such as phthalates. We have previously demonstrated that women planning a pregnancy with assisted reproductive technology (ART) have lower phthalate metabolite concentrations than their non-ART-using counterparts.

objectiveTo determine whether women who intended to become pregnant had lower phthalate metabolite concentrations than those who had an unintended pregnancy, or whether change in phthalate exposure across pregnancy differed between these two groups.

methodsA total of 721 women enrolled in The Infant Development and Environment Study (TIDES), a multicentre US prospective pregnancy cohort; 513 (71%) indicated their pregnancy was planned. Urine samples from first- and third-trimester visits were analysed for 10 specific-gravity-adjusted, natural-log-transformed phthalate metabolites. Simple and multivariable linear regression, adjusting for centre, race, age, income, marital status, and parity, were employed to determine whether phthalate metabolite concentrations differed by pregnancy intention.

resultsIn bivariate analyses, the geometric mean concentrations of all first-trimester and most third-trimester phthalates were higher in women with unplanned pregnancies. However, after covariate adjustment, only first-trimester monoisobutyl phthalate (MiBP) remained associated with pregnancy intention, and the association changed direction such that unplanned pregnancies had lower MiBP concentrations (ß -0.18, 95% CI -0.35, -0.02).

conclusionsWe did not find evidence of a difference in phthalate exposure between pregnancy planners and non-planners.

Indexed as

Environmental PollutantsPhthalic AcidsChildChild DevelopmentFemaleHumansInfantIntentionMaternal ExposurePregnancyPregnant PeopleProspective StudiesEnvironmental Pollutantsphthalic acidPhthalic Acidsendocrine disruptorsphthalic acidspreconception carepregnancyunplanned pregnancy

Identifiers

PMID32249967
PMCPMC7541656

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.