Evidence map›Paper›PMID 32249917›Full record

ArticleThe Journal of infectious diseases2020

Relationships Between Measures of Malaria at Delivery and Adverse Birth Outcomes in a High-Transmission Area of Uganda.

John Ategeka, Abel Kakuru, Richard Kajubi, Razack Wasswa, Harriet Ochokoru, Emmanuel Arinaitwe, Adoke Yeka, Prasanna Jagannathan, Moses R Kamya, Atis Muehlenbachs and 2 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02793622 (Prevention of Malaria in HIV-uninfected Pregnant Women and Infants), which is not on this map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02793622 phase3completednot on this map

Prevention of Malaria in HIV-uninfected Pregnant Women and Infants

TypeinterventionalSponsorUniversity of California, San FranciscoRan2016 to 2018Enrolled782ConditionsMalariaArmsMonthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy, Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  13. Placental Malaria.Current tropical medicine reports · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

John AtegekaInfectious Diseases Research Collaboration, Kampala, Uganda.
Abel KakuruInfectious Diseases Research Collaboration, Kampala, Uganda.
Richard KajubiInfectious Diseases Research Collaboration, Kampala, Uganda.
Razack WasswaInfectious Diseases Research Collaboration, Kampala, Uganda.
Harriet OchokoruInfectious Diseases Research Collaboration, Kampala, Uganda.
Emmanuel ArinaitweInfectious Diseases Research Collaboration, Kampala, Uganda.
Adoke YekaInfectious Diseases Research Collaboration, Kampala, Uganda.
Prasanna JagannathanDepartment of Medicine, Stanford University, Stanford, California, USA.
Moses R KamyaSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Atis MuehlenbachsCenters for Disease Control and Prevention, Atlanta, Georgia, USA.
R Matthew ChicoLondon School of Hygiene and Tropical Medicine, London, United Kingdom.
Grant DorseyDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Infectious Diseases Research Collaboration · UGLondon School of Hygiene & Tropical Medicine · GBCenters for Disease Control and Prevention · USMakerere University · UGStanford University · USUniversity of California, San Francisco · US

Funding

The immunologic consequences of prenatal exposure to malariaP01HD059454 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHARLEBOIS, EDWIN DUNCAN · 2008 to 2017
$22.6M
Training In Malaria Research in UgandaD43TW007375 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2005 to 2019
$2.9M
FIC NIH HHS D43 TW007375NICHD NIH HHS P01 HD059454
6 · The paper itself

Abstract

backgroundClinical trials of interventions for preventing malaria in pregnancy often use measures of malaria at delivery as their primary outcome. Although the objective of these interventions is to improve birth outcomes, data on associations between different measures of malaria at delivery and adverse birth outcomes are limited.

methodsData came from 637 Ugandan women enrolled in a randomized controlled trial of intermittent preventive treatment of malaria in pregnancy. Malaria at delivery was detected using peripheral and placental blood microscopy, placental blood loop-mediated isothermal amplification (LAMP), and placental histopathology. Multivariate analyses were used to estimate associations between measures of malaria at delivery and risks of low birth weight (LBW), small for gestational age (SGA), and preterm birth (PTB).

resultsDetection of malaria parasites by microscopy or LAMP was not associated with adverse birth outcomes. Presence of malaria pigment detected by histopathology in ≥30% of high-powered fields was strongly associated with LBW (adjusted risk ratio [aRR] = 3.42, P = .02) and SGA (aRR = 4.24, P < .001) but not PTB (aRR = 0.88, P = .87).

conclusionsA semiquantitative classification system based on histopathologically detected malaria pigment provided the best surrogate measure of adverse birth outcomes in a high-transmission setting and should be considered for use in malaria in pregnancy intervention studies.

Indexed as

Infant, Low Birth WeightInfant, Small for Gestational AgePremature BirthAdolescentAdultAntimalarialsDrug CombinationsFemaleHumansInfant, NewbornMalariaMicroscopyMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesParturitionPlacentaAntimalarialsDrug Combinationsfanasil, pyrimethamine drug combinationPyrimethamineSulfadoxinelow birth weightmalaria in pregnancyplacental malariapreterm birthsmall for gestational age

Identifiers

PMID32249917
PMCPMC7399701
OpenAlexW3014320103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.