Evidence map›Paper›PMID 32249904›Full record

ArticleBioscience reports2020

iTRAQ-based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture.

Yanan Xu, Xian Li, Duriwa Man, Xiulan Su, Gula A

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Proteomics Reveals Molecular Changes in Insomnia Patients with More Dreams.Computational and mathematical methods in medicine · 2022
    Article
  13. Effects of Alcohol Extracts FromFrontiers in nutrition · 2022
    Article
  14. Article
  15. Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy.Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yanan XuClinical Medicine Research Center of Affiliated Hospital, Inner Mongolia Medical University, No.1 Tongdao North Street, Hohhot, Inner Mongolia 010050, China.
Xian LiClinical Medicine Research Center of Affiliated Hospital, Inner Mongolia Medical University, No.1 Tongdao North Street, Hohhot, Inner Mongolia 010050, China.
Duriwa ManInner Mongolia Medical University, No.1 Tongdao North Street, Hohhot, Inner Mongolia 010050, China.
Xiulan SuClinical Medicine Research Center of Affiliated Hospital, Inner Mongolia Medical University, No.1 Tongdao North Street, Hohhot, Inner Mongolia 010050, China.
Gula AInner Mongolia Medical University, No.1 Tongdao North Street, Hohhot, Inner Mongolia 010050, China.
Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the proteomic changes in the hypothalamus of rats treated with Mongolian medical warm acupuncture for insomnia therapy based proteomics.

methodWe used an iTRAQ-based quantitative proteomic approach to identify proteins that potential molecular mechanisms involved in the treatment of insomnia by Mongolian medical warm acupuncture.

resultIn total, 7477 proteins were identified, of which 36 proteins showed increased levels and 45 proteins showed decreased levels in insomnia model group (M) compared with healthy control group (C), 72 proteins showed increased levels and 44 proteins showed decreased levels from the warm acupuncture treated insomnia group (W) compared with healthy controls (C), 28 proteins showed increased levels and 17 proteins showed decreased levels from the warm acupuncture-treated insomnia group (W) compared with insomnia model group (M). Compared with healthy control groups, warm acupuncture-treated insomnia group showed obvious recovered. Bioinformatics analysis indicated that up-regulation of neuroactive ligand-receptor interaction and oxytocin signaling was the most significantly elevated regulate process of Mongolian medical warm acupuncture treatment for insomnia. Proteins showed that increased/decreased expression in the warm acupuncture-treated insomnia group included Prolargin (PRELP), NMDA receptor synaptonuclear-signaling and neuronal migration factor (NSMF), Transmembrane protein 41B (TMEM41B) and Microtubule-associated protein 1B (MAP1B) to adjust insomnia.

conclusionA combination of findings in the present study suggest that warm acupuncture treatment is efficacious in improving sleep by regulating the protein expression process in an experimental rat model and may be of potential benefit in treating insomnia patients with the added advantage with no adverse effects.

Indexed as

Acupuncture TherapyAnimalsDisease Models, AnimalExtracellular Matrix ProteinsFenclonineHumansHypothalamusMaleMedicine, Mongolian TraditionalMicrotubule-Associated ProteinsNerve Tissue ProteinsOxytocinProteomicsRatsSleep Initiation and Maintenance DisordersUp-RegulationExtracellular Matrix ProteinsFencloninemicrotubule-associated protein 1BMicrotubule-Associated ProteinsNerve Tissue ProteinsNsmf protein, ratOxytocinPrelp protein, ratinsomniaiTRAQproteomicsTraditional Mongolian medicinewarm acupuncture

Identifiers

PMID32249904
PMCPMC7953503
OpenAlexW3014455357

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.