ArticleScientific reports2020
Massive analysis of 64,628 bacterial genomes to decipher water reservoir and origin of mobile colistin resistance genes: is there another role for these enzymes?
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 72 citations in OpenAlex.
- Reduced Susceptibility to Cefiderocol Among Clinical MCR-1-ProducingAntibiotics (Basel, Switzerland) · 2026Article
- Acquired mutations in transcriptional regulatorAntimicrobial agents and chemotherapy · 2026Article
- MCR-3 and MCR-9 confer species-specific increases in colistin MICs.Microbiology (Reading, England) · 2026Article
- First report and genomic characterization of an mcr-10.1-carrying Enterobacter kobei strain isolated from a domestic kitchen sink in China.BMC microbiology · 2026Article
- Dissemination dynamics of colistin resistance genes mcr-9 and mcr-10 across diverse Inc plasmid backbones.Communications medicine · 2025Article
- Freshwater snail faecal metagenomes reveal environmental reservoirs of antimicrobial resistance genes across two continents.Microbial genomics · 2025Article
- Clinical and microbiological analyses of colistin-resistant strains among carbapenem-resistantMicrobiology spectrum · 2025Article
- Article
- Site-selective modifications by lipid A phosphoethanolamine transferases linked to colistin resistance and bacterial fitness.mSphere · 2024Article
- The multifaceted roles of phosphoethanolamine-modified lipopolysaccharides: from stress response and virulence to cationic antimicrobial resistance.Microbiology and molecular biology reviews : MMBR · 2024Review
- Review
- Mobile Colistin-Resistant GenesAntibiotics (Basel, Switzerland) · 2024Article
- Plasmid-mediatedAntimicrobial agents and chemotherapy · 2023Article
- First Detection ofAntibiotics (Basel, Switzerland) · 2023Article
- Molecular epidemiology and genomic characterization of a plasmid-mediatedComputational and structural biotechnology journal · 2023Article
- Optimized Design of Degenerate Primers for PCR Based on DNA or Protein Sequence Comparisons.Methods in molecular biology (Clifton, N.J.) · 2023Article
- More thanFrontiers in cellular and infection microbiology · 2023Article
- Frequent convergence ofEmerging microbes & infections · 2022Article
- Genomic Analysis of aAntibiotics (Basel, Switzerland) · 2022Article
- First Report of the Colistin Resistance GeneMicrobiology spectrum · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since 2015, new worrying colistin resistance mechanism, mediated by mcr-1 gene has been reported worldwide along with eight newly described variants but their source(s) and reservoir(s) remain largely unexplored. Here, we conducted a massive bioinformatic analysis of bacterial genomes to investigate the reservoir and origin of mcr variants. We identified 13'658 MCR-1 homologous sequences in 494 bacterial genera. Moreover, analysis of 64'628 bacterial genomes (60 bacterial genera and 1'047 species) allows identifying a total of 6'651 significant positive hits (coverage >90% and similarity >50%) with the nine MCR variants from 39 bacterial genera and more than 1'050 species. A high number of MCR-1 was identified in Escherichia coli (n = 862). Interestingly, while almost all variants were identified in bacteria from different sources (i.e. human, animal, and environment), the last variant, MCR-9, was exclusively detected in bacteria from human. Although these variants could be identified in bacteria from human and animal sources, we found plenty MCR variants in unsuspected bacteria from environmental origin, especially from water sources. The ubiquitous presence of mcr variants in bacteria from water likely suggests another role in the biosphere of these enzymes as an unknown defense system against natural antimicrobial peptides and/or bacteriophage predation.
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