Evidence map›Paper›PMID 32249820›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2020

Characterization of cervical biopsies of women with HIV and HPV co-infection using p16

Wieke W Kremer, Frederique J Vink, Marjolein van Zummeren, Greta Dreyer, Lawrence Rozendaal, John Doorbar, Maaike C G Bleeker, Chris J L M Meijer

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Wieke W KremerAmsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6903-1505
Frederique J VinkAmsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4951-9167
Marjolein van ZummerenAmsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Greta DreyerDepartment of Obstetrics and Gynecology, University of Pretoria, Pretoria, South Africa.
Lawrence RozendaalAmsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
John DoorbarDepartment of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.
Maaike C G BleekerAmsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Chris J L M MeijerAmsterdam UMC, Vrije Universiteit Amsterdam, Pathology, Cancer Center Amsterdam, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. cjlm.meijer@amsterdamumc.nl.
Amsterdam University Medical Centers · NLAmsterdam Neuroscience · NLUniversity of Cambridge · GBUniversity of Pretoria · ZA

Funding

Cancer Research UK 28754Medical Research Council MR/S024409/1
6 · The paper itself

Abstract

This study aims to characterize cervical intraepithelial neoplasia (CIN) in women living with HIV using biomarkers. Immunohistochemical (IHC) staining for human papillomavirus (HPV) E4 protein indicates CIN with productive HPV infection, whereas Ki-67 and p16

Indexed as

AdultBiomarkers, TumorBiopsyCoinfectionCyclin-Dependent Kinase Inhibitor p16DNA MethylationFemaleHIV InfectionsHumansImmunohistochemistryKi-67 AntigenMiddle AgedNeoplasm GradingOncogene Proteins, ViralPapillomavirus InfectionsUterine Cervical DysplasiaBiomarkers, TumorCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Ki-67 AntigenOncogene Proteins, Viral

Identifiers

PMID32249820
OpenAlexW3014469787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.