ArticleScientific reports2020
The honeybee (Apis mellifera) developmental state shapes the genetic composition of the deformed wing virus-A quasispecies during serial transmission.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Experimental infection of acute bee paralysis virus induces differential responses of selected honey bee immune genes, independent of varroa resistance.Scientific reports · 2026Article
- The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host.BMC genomics · 2025Article
- Solenopsis richteri (Hymenoptera: Formicidae) alates infected with deformed wing virus display wing deformity with altered mobility.Die Naturwissenschaften · 2024Article
- Origins, diversity, and adaptive evolution of DWV in the honey bees of the Azores: the impact of the invasive miteVirus evolution · 2024Article
- Doomed drones? Using passage experiments and mathematical modelling to determine Deformed wing virus population dynamics in male honeybees.Proceedings. Biological sciences · 2023Article
- Vector-virus interaction affects viral loads and co-occurrence.BMC biology · 2022Article
- Virus Prevalence in Egg Samples Collected from Naturally Selected and Traditionally Managed Honey Bee Colonies across Europe.Viruses · 2022Article
- Transmission of deformed wing virus between Varroa destructor foundresses, mite offspring and infested honey bees.Parasites & vectors · 2022Article
- Honey Bee Genetic Stock Determines Deformed Wing Virus Symptom Severity but not Viral Load or Dissemination Following Pupal Exposure.Frontiers in genetics · 2022Article
- Simulated vector transmission differentially influences dynamics of two viral variants of deformed wing virus in honey bees (The Journal of general virology · 2021Article
- Virus Prospecting in Crickets-Discovery and Strain Divergence of a Novel Iflavirus in Wild and CultivatedViruses · 2021Article
- Tolerance of Honey Bees toViruses · 2020Article
- Pesticide-Virus Interactions in Honey Bees: Challenges and Opportunities for Understanding Drivers of Bee Declines.Viruses · 2020Review
- Bee Viruses: Routes of Infection in Hymenoptera.Frontiers in microbiology · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main biological threat to the western honeybee (Apis mellifera) is the parasitic mite Varroa destructor, largely because it vectors lethal epidemics of honeybee viruses that, in the absence of this mite, are relatively innocuous. The severe pathology is a direct consequence of excessive virus titres caused by this novel transmission route. However, little is known about how the virus adapts genetically during transmission and whether this influences the pathology. Here, we show that upon injection into honeybee pupae, the deformed wing virus type-A (DWV-A) quasispecies undergoes a rapid, extensive expansion of its sequence space, followed by strong negative selection towards a uniform, common shape by the time the pupae have completed their development, with no difference between symptomatic and asymptomatic adults in either DWV titre or genetic composition. This suggests that the physiological and molecular environment during pupal development has a strong, conservative influence on shaping the DWV-A quasispecies in emerging adults. There was furthermore no evidence of any progressive adaptation of the DWV-A quasispecies to serial intra-abdominal injection, simulating mite transmission, despite the generation of ample variation immediately following each transmission, suggesting that the virus either had already adapted to transmission by injection, or was unaffected by it.
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