ArticleNature communications2020
Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
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Who cites it
158 citing papers in PubMed, 254 citations in OpenAlex.
- Infection cycles of viruses of the phylum Nucleocytoviricota.Nature reviews. Microbiology · 2026Review
- Evidence for the acquisition of a proteorhodopsin-like rhodopsin by a chrysophyte-infecting giant virus.Journal of virology · 2026Article
- Molecular mechanism of calcium inhibition in viral channelrhodopsins.Nature communications · 2026Article
- The factory enters the fray: how mitochondrial protein trafficking shapes the host response to infection.Journal of virology · 2026Review
- Genomic catalogue of giant viruses reveals expanded diversity and functional potential.Nature microbiology · 2026Article
- Widespread genomic islands are hotspots of genome variations and mosaicism in giant viruses.Nature communications · 2026Article
- Mycodnaviridae is a clade of giant viruses that persistently infect zoosporic fungi.PLoS biology · 2026Article
- GiantHost: a domain-adaptive and uncertainty-aware framework for giant virus host prediction.Bioinformatics (Oxford, England) · 2026Article
- Horizontal transfer of a 180-kbp genomic fraction among the largest viral genomes.Applied and environmental microbiology · 2026Article
- Refining a giant virus lineage: a novel order unifyingJournal of virology · 2026Article
- Giant viruses of the polar regions: diversity, endemism, adaptation and ecological structuring.FEMS microbiology ecology · 2026Review
- Review
- Rise of the viral giants: common themes underlying genome gigantism in eukaryotic viruses and bacteriophages.Current opinion in microbiology · 2026Review
- Giant viruses rewire control of cellular protein synthesis.Nature microbiology · 2026Article
- Metagenomic insights into viral and microbial genes of Russian High-Arctic soil microbiomes.Communications biology · 2026Article
- Unveiling the cryptic diversity and distribution of elements related to virophage mavirus through deep mining of pPolB proteins.Virologica Sinica · 2026Article
- Unveiling the biodiversity of large DNA viruses in intertidal mudflats via metagenomics.Nature communications · 2026Article
- Diving into the hidden viral world of marine protists.Journal of virology · 2026Review
- A genomic view of Earth's biomes.Nature reviews. Genetics · 2026Review
- Widespread and intron-rich mirusviruses are predicted to reproduce in nuclei of unicellular eukaryotes.Nature microbiology · 2026Article
98 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of eukaryotic giant viruses has transformed our understanding of the limits of viral complexity, but the extent of their encoded metabolic diversity remains unclear. Here we generate 501 metagenome-assembled genomes of Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) from environments around the globe, and analyze their encoded functional capacity. We report a remarkable diversity of metabolic genes in widespread giant viruses, including many involved in nutrient uptake, light harvesting, and nitrogen metabolism. Surprisingly, numerous NCLDV encode the components of glycolysis and the TCA cycle, suggesting that they can re-program fundamental aspects of their host's central carbon metabolism. Our phylogenetic analysis of NCLDV metabolic genes and their cellular homologs reveals distinct clustering of viral sequences into divergent clades, indicating that these genes are virus-specific and were acquired in the distant past. Overall our findings reveal that giant viruses encode complex metabolic capabilities with evolutionary histories largely independent of cellular life, strongly implicating them as important drivers of global biogeochemical cycles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.