Observational studyArthritis & rheumatology (Hoboken, N.J.)2020
Defining Clinical Subgroups in Relapsing Polychondritis: A Prospective Observational Cohort Study.
Observational study in Arthritis & rheumatology (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Performance Characteristics of Anti-Collagen II Antibodies in Relapsing Polychondritis and Related Diseases: Prospective Analysis, Systematic Review, and Meta-Analysis.Arthritis care & research · 2026Pooled it
- Diagnosis and treatment strategies for airway involvement in relapsing polychondritis: a comprehensive review.Frontiers in immunology · 2026Pooled it
- Otorhinolaryngological manifestations of systemic autoimmune and autoinflammatory diseases: a comprehensive review.Immunologic research · 2026Review
- Evaluating clinical heterogeneity in relapsing polychondritis through unsupervised cluster analysis.Arthritis research & therapy · 2026Article
- Unveiling the clinical and proteomic spectrum of relapsing polychondritis with respiratory involvement.Frontiers in immunology · 2026Article
- Benign subglottic stenosis from a rheumatologist' perspective: a narrative review.Clinical rheumatology · 2025Review
- A case of tracheobronchomegaly misdiagnosed as COPD: case report and literature review.BMC pulmonary medicine · 2025Review
- Demographic, clinical, treatment, outcome, and comorbidities of patients with relapsing polychondritis: experience from Brazilian tertiary center, and literature review.Advances in rheumatology (London, England) · 2025Review
- Clinical Manifestations and Treatment in Patients With Relapsing Polychondritis: A Multicenter Observational Cohort Study.ACR open rheumatology · 2025Article
- Relapsing Polychondritis Associated With Thyroid Carcinoma: A First Malagasy Case.Case reports in otolaryngology · 2025Article
- Relapsing polychondritis following PD-1 blockade diagnosed via 18F-FDG PET/CT and improved by steroid administration: a case report and literature review.Frontiers in immunology · 2025Review
- Distribution of Airway Findings in ANCA-Associated Vasculitis: A 20-Year Observational Analysis.Diagnostics (Basel, Switzerland) · 2024Article
- Relapsing polychondritis: clinical updates and new differential diagnoses.Nature reviews. Rheumatology · 2024Review
- [Relapsing polychondritis].Zeitschrift fur Rheumatologie · 2023Article
- Imaging features and clinical value ofArthritis research & therapy · 2023Article
- The ocular manifestations of relapsing polychondritis.International ophthalmology · 2023Article
- Progress and challenges in the use of blood biomarkers in relapsing polychondritis.Clinical and experimental immunology · 2023Review
- Relapsing polychondritis: focus on cardiac involvement.Frontiers in immunology · 2023Article
- Relapsing polychondritis with isolated tracheobronchial involvement complicated with Sjogren's syndrome: A case report.World journal of clinical cases · 2022Article
- Comparison of relapsing polychondritis patients with and without respiratory involvement based on chest computed tomography: a retrospective cohort study.BMC pulmonary medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveRelapsing polychondritis (RP) is a systemic disease. Failure to recognize RP can lead to diagnostic delay and further complications, including death. This study was undertaken to identify clinical patterns in a prospective cohort of patients with RP.
methodsPatient subgroups were identified using latent class analysis based on 8 clinical variables: saddle-nose deformity, subglottic stenosis, tracheomalacia, bronchomalacia, ear chondritis, tenosynovitis/synovitis, inflammatory eye disease, and audiovestibular disease. Model selection was based on Akaike's information criterion.
resultsSeventy-three patients were included in this study. Patients were classified into 1 of 3 subgroups: type 1 RP (14%), type 2 RP (29%), and type 3 RP (58%). Type 1 RP was characterized by ear chondritis (100%), tracheomalacia (100%), saddle-nose deformity (90%), and subglottic stenosis (80%). These patients had the shortest median time to diagnosis (1 year), highest disease activity, and greatest frequency of admission to the intensive care unit and tracheostomy. Type 2 RP was characterized by tracheomalacia (100%) and bronchomalacia (52%), but no saddle-nose deformity or subglottic stenosis. These patients had the longest median time to diagnosis (10 years) and highest percentage of work disability. Type 3 RP was characterized by tenosynovitis/synovitis (60%) and ear chondritis (55%). There were no significant differences in sex, race, or treatment strategies between the 3 subgroups.
conclusionOur findings indicate that there are 3 subgroups of patients with RP, with differences in time to diagnosis, clinical and radiologic characteristics, and disease-related complications. Recognizing a broader spectrum of clinical patterns in RP, beyond cartilaginous involvement of the ear and upper airway, may facilitate more timely diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.