Evidence map›Paper›PMID 32249357›Full record

ArticleActa diabetologica2020

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic.

Livio Luzi, Maria Grazia Radaelli

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta diabetologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 16 pooled it
52.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 16 syntheses or guidelines pooled it, 391 citations in OpenAlex.

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  11. Obesity is a risk factor for developing critical condition in COVID-19 patients: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020
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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Livio LuziDepartment of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Milan, Italy. livio.luzi@multimedica.it.
Maria Grazia RadaelliDepartment of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Milan, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITMultiMedica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAnalyze the relationship between obesity and influenza.

methodsBasal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral strain, prolongs the virus shedding throughout the total population and eventually might increase overall mortality rate of an influenza pandemic.

resultsWaiting for the development of a vaccination against COVID-19, isolation of positive cases and social distancing are the primary interventions. Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise.

conclusionsDue to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.

Indexed as

BetacoronavirusCoronavirus InfectionsCOVID-19HumansInfluenza, HumanObesityPandemicsPneumonia, ViralPrevalenceQuarantineSARS-CoV-2Virus SheddingCOVID-19Immune-modulationInfluenzaObese subjects

Identifiers

PMID32249357
PMCPMC7130453
OpenAlexW3015049708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.