Evidence map›Paper›PMID 32249341›Full record

ArticleProgress in orthodontics2020

Association between craniofacial morphological patterns and tooth agenesis-related genes.

Amanda Silva Rodrigues, Ellen Cardoso Teixeira, Leonardo Santos Antunes, Paulo Nelson-Filho, Arthur Silva Cunha, Simone Carvalho Levy, Mônica Tirre de Souza Araújo, Alice Gomes de Carvalho Ramos, Giuseppe Valduga Cruz, Marjorie Ayumi Omori and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in orthodontics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  7. Tooth number abnormality: from bench to bedside.International journal of oral science · 2023
    Review
  8. The association of polymorphisms inSaudi journal of biological sciences · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Amanda Silva RodriguesSchool of Dentistry, Fluminense Federal University, Rua São Paulo 28, Campus do Valonguinho, Niterói, RJ, 24020-150, Brazil.
Ellen Cardoso TeixeiraSchool of Dentistry, Fluminense Federal University, Rua Doutor Sílvio Henrique Braune 22, Niterói, Nova Friburgo, RJ, 28625-650, Brazil.
Leonardo Santos AntunesSchool of Dentistry, Fluminense Federal University, Rua Doutor Sílvio Henrique Braune 22, Niterói, Nova Friburgo, RJ, 28625-650, Brazil.
Paulo Nelson-FilhoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n-Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil.
Arthur Silva CunhaDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n-Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil.
Simone Carvalho LevySchool of Dentistry, Fluminense Federal University, Rua São Paulo 28, Campus do Valonguinho, Niterói, RJ, 24020-150, Brazil.
Mônica Tirre de Souza AraújoDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco, 325-Cidade Universitária, Rio de Janeiro, RJ, 21941-617, Brazil.
Alice Gomes de Carvalho RamosAmazonian Education Institute, Rua Maceió 861, Adrianópolis, Manaus, AM, 69057-010, Brazil.
Giuseppe Valduga CruzDepartment of Oral and Maxillofacial Surgery, Positivo University, Rua Professor Pedro Viriato Parigot de Souza 5300-Campo Comprido, Curitiba, PR, 81200-452, Brazil.
Marjorie Ayumi OmoriDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n-Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil.
Mírian Aiko Nakane MatsumotoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n-Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil.
Alexandre Rezende VieiraDepartment of Oral Biology, School of Dental Medicine, University of Pittsburgh, 412 Salk Pavilion, 335 Sutherland Street, Pittsburgh, PA, 15261, USA.
Erika Calvano KüchlerDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n-Campus da USP, Ribeirão Preto, SP, 14040-904, Brazil.
Guido Artemio Marañón-VásquezDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco, 325-Cidade Universitária, Rio de Janeiro, RJ, 21941-617, Brazil. guido_amv@hotmail.com.
Lívia Azeredo Alves AntunesSchool of Dentistry, Fluminense Federal University, Rua São Paulo 28, Campus do Valonguinho, Niterói, RJ, 24020-150, Brazil. liviaazeredo@gmail.com.
Universidade de São Paulo · BRUniversidade Federal Fluminense · BRUniversidade Federal do Rio de Janeiro · BRUniversidade Positivo · BRUniversity of Pittsburgh · US

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/06866-5
6 · The paper itself

Abstract

backgroundThe aim of the present study was to assess if genetic polymorphisms in tooth agenesis (TA)-related genes are associated with craniofacial morphological patterns.

methodsThis cross-sectional, multi-center, genetic study evaluated 594 orthodontic Brazilians patients. The presence or absence of TA was determined by analysis of panoramic radiography. The patients were classified according to their skeletal malocclusion and facial growth pattern by means of digital cephalometric analysis. Genomic DNA was extracted from squamous epithelial cells of buccal mucosa and genetic polymorphisms in MSX1 (rs1042484), PAX9 (rs8004560), TGF-α (rs2902345), FGF3 (rs1893047), FGF10 (rs900379), and FGF13 (rs12838463, rs5931572, and rs5974804) were genotyped by polymerase chain reaction using TaqMan chemistry and end-point analysis.

resultsGenotypes (p = 0.038) and allele (p = 0.037) distributions for the FGF3 rs1893047 were significantly different according to the skeletal malocclusion. Carrying at least one G allele increased in more than two times the chance of presenting skeletal class III malocclusion (OR = 2.21, CI 95% = 1.14-4.32; p = 0.017). There was no association between another skeletal craniofacial pattern and some polymorphism assessed in the present study.

conclusionOur results suggest that the genetic polymorphism rs1893047 in FGF3 might contribute to variations in the craniofacial sagittal pattern.

Indexed as

AnodontiaMalocclusionBrazilCephalometryCross-Sectional StudiesGenotypeHumansAnodontiaGeneticMaxillofacial developmentPolymorphism

Identifiers

PMID32249341
PMCPMC7131971
OpenAlexW3014121854

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.