ArticleExperimental brain research2020
StartReact increases the probability of muscle activity and distance in severe/moderate stroke survivors during two-dimensional reaching task.
Article in Experimental brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Electroacupuncture for Motor Recovery in Subacute Stroke: A Randomized Trial Exploring CReST-Related Modulation.Brain and behavior · 2026Trial
- What Is the StartReact Effect?Acta physiologica (Oxford, England) · 2026Review
- Association of a kinematic measure of upper limb reaching and StartReact in chronic hemiparetic stroke.Experimental brain research · 2025Article
- The interplay of perceptual processing demands and practice in modulating voluntary and involuntary motor responses.Psychophysiology · 2024Article
- An intense electrical stimulus can elicit a StartReact effect but with decreased incidence and later onset of the startle reflex.Experimental brain research · 2024Article
- Startle-triggered responses indicate reticulospinal drive is larger for voluntary shoulder versus finger movements.Scientific reports · 2023Article
- Altered frontoparietal activity in acoustic startle priming tasks during reticulospinal tract facilitation: An fNIRS study.Frontiers in neuroscience · 2023Article
- The Existence of the StartReact Effect Implies Reticulospinal, Not Corticospinal, Inputs Dominate Drive to Motoneurons during Voluntary Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Influence of task complexity on movement planning and release after stroke: insights from startReact.Experimental brain research · 2022Article
- Does exposure to startle impact voluntary reaching movements in individuals with severe-to-moderate stroke?Experimental brain research · 2021Article
- Startle Increases the Incidence of Anticipatory Muscle Activations but Does Not Change the Task-Specific Muscle Onset for Patients After Subacute Stroke.Frontiers in neurology · 2021Article
- Butylphthalide soft capsules combined with modified tonic exercise therapy on neurological function and ability of daily living of patients with stroke hemiplegia.American journal of translational research · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
StartReact elicits faster, larger, and more appropriate muscle activation in stroke survivors but has been only cursorily studied to date during multi-jointed reaching. Our objective was to evaluate StartReact on unrestricted, two-dimensional point-to-point reaching tasks post-stroke. Data from 23 individuals with stroke were collected during point-to-point reaching. Voluntary and StartReact trials were compared between mild, severe/moderate, and the unimpaired arm. StartReact showed an increase in probability of muscle activity, larger muscle activity amplitude, and faster muscle activity onset. Despite changes in muscle activity, metrics of movement (distance, final error, linear deviation) were not different between StartReact and Voluntary trials except in severe/moderate stroke who had larger reaching distances during StartReact. While StartReact impacted many metrics of muscle activity, the most profound effect was on the probability of muscle activity increasing 34% compared to voluntary which allowed severe/moderate subjects to increase reaching distance but did not translate to decrease in final error suggesting that the additional movement was not always directed towards the appropriate target. These results indicate that SR has the capacity to activate paralyzed muscle in severe/moderate patients, but future studies are needed to explore the possible use of SR in the rehabilitation.
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