ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2020
Saliva Preparation Method Exploration for ATR-FTIR Spectroscopy: Towards Bio-fluid Based Disease Diagnosis.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 14 citations in OpenAlex.
- Rapid diagnosis of alprazolam poisoning by Fourier transform infrared spectroscopy on saliva samples.Scientific reports · 2025Article
- The Role of the Preanalytical Step for Human Saliva Analysis via Vibrational Spectroscopy.Metabolites · 2023Article
- Article
- Infrared Based Saliva Screening Test for COVID-19.Angewandte Chemie (International ed. in English) · 2021Article
- Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples.Molecules (Basel, Switzerland) · 2020Review
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4 authors at 1 institution in 1 country.
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Abstract
Saliva has garnered a lot of interest as a non-invasive, easy to collect, and biochemical rich sample for attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) based disease diagnosis. Although a large number of studies have explored its potential, the preparation methods used differ greatly. For large scale clinical studies to aid translation into clinics, the collection/processing methodology needs to be standardized. Therefore, in this study, we explored different saliva collection (spitting, method A/cotton soaking, method B) and processing protocols (unprepared, TS; supernatant from the centrifugation, CS; and drying, C) to find which gives the best ATR-FTIR signals. Analysis showed highest proteins, carbohydrates, amino acids, and nucleic acid + proteins/lipids in BTS, BCS, ACS, and BC, respectively. Notably, only BC shows a 1377 cm
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