ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020
A mechanism for learning with sleep spindles.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 97 citations in OpenAlex.
- The effect of zolpidem on targeted memory reactivation during sleep.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Trial
- Replay of procedural memory is independent of the hippocampus.Nature neuroscience · 2026Article
- Respiratory pauses highlight sleep architecture in mice.Nature communications · 2026Article
- Sleep stage-specific effects of 0.75 Hz phase-synchronized rTMS and tACS on delta frequency activity during sleep.Scientific reports · 2026Article
- Visual Training Induced Temporo-Occipital Fast Sleep Spindle Clustering in Humans Revealed by Full-Night HD-EEG Recordings.Journal of sleep research · 2026Article
- Infant sleep EEG features at 4 months as biomarkers of neurodevelopment at 18 months.Pediatric research · 2025Article
- Changes to human sleep architecture during long-duration spaceflight.Journal of sleep research · 2025Article
- A Role for δ Subunit-Containing GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pathological respiratory chemoreflex activation predicts improvement of neurocognitive function in response to continuous positive airway pressure therapy.Frontiers in neuroscience · 2025Article
- Differences in brain spindle density during sleep between patients with and without type 2 diabetes.Computers in biology and medicine · 2025Article
- Acute Sleep Deprivation Suppresses Sleep Spindles in Mice.Nature and science of sleep · 2025Article
- Coupling of Slow Oscillations in the Prefrontal and Motor Cortex Predicts Onset of Spindle Trains and Persistent Memory Reactivations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Oscillatory-Quality of sleep spindles links brain state with sleep regulation and function.Science advances · 2024Article
- Slow-wave sleep drives sleep-dependent renormalization of synaptic AMPA receptor levels in the hypothalamus.PLoS biology · 2024Article
- Prefrontal cortical ripples mediate top-down suppression of hippocampal reactivation during sleep memory consolidation.Current biology : CB · 2024Article
- Differences in sleep spindle wave density between patients with diabetes mellitus and matched controls: implications for sensing and regulation of peripheral blood glucose.medRxiv : the preprint server for health sciences · 2024Article
- Neural oscillations and memory: unraveling the mechanisms of anesthesia-induced amnesia.Frontiers in neuroscience · 2024Review
- Development of slow oscillation-spindle coupling from infancy to toddlerhood.Sleep advances : a journal of the Sleep Research Society · 2024Article
- A Thalamocortical Perspective on Sleep Spindle Alterations in Neurodevelopmental Disorders.Current sleep medicine reports · 2024Review
- Neural reactivation during human sleep.Emerging topics in life sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Spindles are ubiquitous oscillations during non-rapid eye movement (NREM) sleep. A growing body of evidence points to a possible link with learning and memory, and the underlying mechanisms are now starting to be unveiled. Specifically, spindles are associated with increased dendritic activity and high intracellular calcium levels, a situation favourable to plasticity, as well as with control of spiking output by feed-forward inhibition. During spindles, thalamocortical networks become unresponsive to inputs, thus potentially preventing interference between memory-related internal information processing and extrinsic signals. At the system level, spindles are co-modulated with other major NREM oscillations, including hippocampal sharp wave-ripples (SWRs) and neocortical slow waves, both previously shown to be associated with learning and memory. The sequential occurrence of reactivation at the time of SWRs followed by neuronal plasticity-promoting spindles is a possible mechanism to explain NREM sleep-dependent consolidation of memories. This article is part of the Theo Murphy meeting issue 'Memory reactivation: replaying events past, present and future'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.