ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020
Effects of sleep and waking on the synaptic ultrastructure.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Repeated sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons.Molecular brain · 2026Article
- Brain Health from Sleep EEG: A Multicohort, Deep Learning Biomarker for Cognition, Disease, and Mortality.NEJM AI · 2026Article
- Article
- Induction of cortical ON/OFF periods in awake mice fulfills sleep functions.bioRxiv : the preprint server for biology · 2025Article
- Heterogeneous synaptic homeostasis: A novel mechanism boosting information propagation in the cortex.PLoS computational biology · 2025Article
- Sleep maintains excitatory synapse diversity in the cortex and hippocampus.Current biology : CB · 2024Article
- Effects of non-rapid eye movement sleep on the cortical synaptic expression of GluA1-containing AMPA receptors.The European journal of neuroscience · 2024Article
- Non-rapid eye movement sleep slow-wave activity features are associated with amyloid accumulation in older adults with obstructive sleep apnoea.Brain communications · 2024Article
- Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.Brain and behavior · 2023Article
- Article
- Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning.Journal of neuroinflammation · 2023Article
- How sleep shapes what we remember-and forget.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Exploiting volume electron microscopy to investigate structural plasticity and stability of the postsynaptic compartment of central synapses.Frontiers in cellular neuroscience · 2023Review
- Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum.eLife · 2022Article
- Sleep function: an evolutionary perspective.The Lancet. Neurology · 2022Review
- Alterations of sleep oscillations in Alzheimer's disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus.Brain research bulletin · 2022Review
- The why and how of sleep-dependent synaptic down-selection.Seminars in cell & developmental biology · 2022Article
- Activation of CNR1/PI3K/AKT Pathway by Tanshinone IIA Protects Hippocampal Neurons and Ameliorates Sleep Deprivation-Induced Cognitive Dysfunction in Rats.Frontiers in pharmacology · 2022Article
- Planetary sleep medicine: Studying sleep at the individual, population, and planetary level.Frontiers in public health · 2022Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We summarize here several studies performed in our laboratory, mainly using serial block-face scanning electron microscopy (SBEM), to assess how sleep, spontaneous waking and short sleep deprivation affect the size and number of synapses in the cerebral cortex and hippocampus. With SBEM, we reconstructed thousands of cortical and hippocampal excitatory, axospinous synapses and compared the distribution of their size after several hours of sleep relative to several hours of waking. Because stronger synapses are on average also bigger, the goal was to test a prediction of the synaptic homeostasis hypothesis, according to which overall synaptic strength increases during waking, owing to ongoing learning, and needs to be renormalized during sleep, to avoid saturation and to benefit memory consolidation and integration. Consistent with this hypothesis, we found that the size of the axon-spine interface (ASI), a morphological measure of synaptic strength, was on average smaller after sleep, but with interesting differences between primary cortex and the CA1 region of the hippocampus. In two-week-old mouse pups, the decline in ASI size after sleep was larger, and affected more cortical synapses, compared with one-month-old adolescent mice, suggesting that synaptic renormalization during sleep may be especially important during early development. This work is still in progress and other brain areas need to be tested after sleep, acute sleep loss and chronic sleep restriction. Still, the current results show that a few hours of sleep or waking lead to significant changes in synaptic morphology that can be linked to changes in synaptic efficacy. This article is part of the Theo Murphy meeting issue 'Memory reactivation: replaying events past, present and future'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.