Evidence map›Paper›PMID 32248731›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Repetitive mTBI is associated with age-related reductions in cerebral blood flow but not cortical thickness.

Alexandra L Clark, Alexandra J Weigand, Katherine J Bangen, Victoria C Merritt, Mark W Bondi, Lisa Delano-Wood

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  9. Cerebral perfusion and amyloidosis in the oldest-old.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  10. Article
  11. Article
  12. Microglial histone deacetylase 2 is dispensable for functional and histological outcomes in a mouse model of traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexandra L ClarkVA San Diego Healthcare System (VASDHS), San Diego, CA, USA.ORCID 0000-0002-7437-5409
Alexandra J WeigandSan Diego State University/University of California, San Diego (SDSU/UCSD) Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Katherine J BangenVA San Diego Healthcare System (VASDHS), San Diego, CA, USA.
Victoria C MerrittVA San Diego Healthcare System (VASDHS), San Diego, CA, USA.
Mark W BondiVA San Diego Healthcare System (VASDHS), San Diego, CA, USA.
Lisa Delano-WoodVA San Diego Healthcare System (VASDHS), San Diego, CA, USA.

Funding

Cerebral Perfusion and Cognitive Outcomes in Mild Traumatic Brain InjuryF31NS098704 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CLARK, ALEXANDRA LEIGH · 2017 to 2018
$74k
NINDS NIH HHS F31 NS098704
6 · The paper itself

Abstract

Mild traumatic brain injury (mTBI) is a risk factor for Alzheimer's disease (AD), and evidence suggests cerebrovascular dysregulation initiates deleterious neurodegenerative cascades. We examined whether mTBI history alters cerebral blood flow (CBF) and cortical thickness in regions vulnerable to early AD-related changes. Seventy-four young to middle-aged Veterans (mean age = 34, range = 23-48) underwent brain scans. Participants were divided into: (1) Veteran Controls (

Indexed as

AdultAge FactorsAlzheimer DiseaseBrain ConcussionCerebrovascular CirculationFemaleHumansMaleaccelerated agingcerebral blood flowcortical thicknessmild TBIrepetitive mTBI

Identifiers

PMID32248731
PMCPMC8369996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.