Evidence map›Paper›PMID 32248720›Full record

ArticleInnate immunity2020

A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway.

Laurent Zablocki-Thomas, Sam A Menzies, Paul J Lehner, Nicolas Manel, Philippe Benaroch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Pathogens (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laurent Zablocki-ThomasInstitut Curie, PSL Research University, INSERM U932, France.ORCID 0000-0001-9917-7815
Sam A MenziesDepartment of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, UK.
Paul J LehnerDepartment of Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, UK.
Nicolas ManelInstitut Curie, PSL Research University, INSERM U932, France.
Philippe BenarochInstitut Curie, PSL Research University, INSERM U932, France.
Inserm · FR

Funding

Medical Research Council MR/V011561/1Wellcome Trust 210688/Z/18/Z
6 · The paper itself

Abstract

A subset of TLRs is specialised in the detection of incoming pathogens by sampling endosomes for nucleic acid contents. Among them, TLR3 senses the abnormal presence of double-stranded RNA in the endosomes and initiates a potent innate immune response via activation of NF-κB and IRF3. Nevertheless, mechanisms governing TLR3 regulation remain poorly defined. To identify new molecular players involved in the TLR3 pathway, we performed a genome-wide screen using CRISPR/Cas9 technology. We generated TLR3

Indexed as

Cells, CulturedChemokine CXCL10Clustered Regularly Interspaced Short Palindromic RepeatsGene Expression RegulationHumansImmunity, InnateInterferon Regulatory Factor-3Interleukin-8MacrophagesMembrane Transport ProteinsNF-kappa BPoly I-CReceptors, Aryl HydrocarbonSignal TransductionToll-Like Receptor 3Chemokine CXCL10CXCL10 protein, humanInterferon Regulatory Factor-3Interleukin-8IRF3 protein, humanMembrane Transport ProteinsNF-kappa BPoly I-CReceptors, Aryl HydrocarbonToll-Like Receptor 3UNC93B1 protein, humanAhRgenetic screeninnate immunityTLRTLR3

Identifiers

PMID32248720
PMCPMC7491238
OpenAlexW3015152138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.