Evidence map›Paper›PMID 32248349›Full record

ReviewJournal of cardiovascular translational research2020

The Role of Cardiac MRI in Animal Models of Cardiotoxicity: Hopes and Challenges.

Carolyn J Park, Mary E Branch, Sujethra Vasu, Giselle C Meléndez

Open access · greenAbstract readReview
In one paragraph

Review in Journal of cardiovascular translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Cardio-Oncology in 2020: Prime for Translation.Journal of cardiovascular translational research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Carolyn J ParkDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Mary E BranchDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Sujethra VasuDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Giselle C MeléndezDepartment of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA. gmelende@wakehealth.edu.
Wake Forest University · US

Funding

CVD Epidemiology Training ProgramT32HL076132 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAVID McLeod HERRINGTON · 2004 to 2026
$8.4M
Cellular Senescence: A Novel Mechanism of Doxorubicin-Induced CardiotoxicityK01HL145329 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MELENDEZ, GISELLE C · 2019 to 2023
$584k
NHLBI NIH HHS K01 HL145329NHLBI NIH HHS K01HL145329NHLBI NIH HHS T32 HL076132NHLBI NIH HHS T32HL076132
6 · The paper itself

Abstract

Animal models of chemotherapy-induced cardiotoxicity have been instrumental in understanding the underlying mechanisms of the disease. The use of cardiac magnetic resonance (CMR) imaging and nuclear magnetic resonance (NMR) imaging in preclinical models allows the non-invasive study of subclinical pathophysiological processes that influence cardiac function and establish imaging parameters that can be adopted into clinical practice to predict cardiovascular outcomes. Given the rising population of cancer survivors and the current lack of effective therapies for the management of cardiotoxicity, research combining clinically relevant animal models and non-invasive cardiac imaging remains essential to improve methods to monitor, predict, and treat cardiovascular adverse events. This comprehensive review summarizes the lessons learned from animal models of cardiotoxicity employing CMR and tissue characterization techniques and discusses the ongoing challenges and hopes for the future.

Indexed as

Antineoplastic AgentsMagnetic Resonance ImagingAnimalsCardiotoxicityDisease Models, AnimalHeart DiseasesHumansPredictive Value of TestsAntineoplastic AgentsCardiac MRICardiotoxicityChemotherapyNuclear magnetic resonance imaging animal models

Identifiers

PMID32248349
PMCPMC7869107
OpenAlexW3014913843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.