ArticleJournal of molecular evolution2020
The Marginal Stability of Proteins: How the Jiggling and Wiggling of Atoms is Connected to Neutral Evolution.
Article in Journal of molecular evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Factors controlling protein evolvability-at the molecular scale.European biophysics journal : EBJ · 2026Article
- Phylogenetic history and temperature adaptation contribute to structural and functional stability of proteins in marine mollusks.Communications biology · 2025Article
- The origin of mutational epistasis.European biophysics journal : EBJ · 2024Article
- Analysis of proteins in the light of mutations.European biophysics journal : EBJ · 2024Review
- Cellular and epigenetic perspective of protein stability and its implications in the biological system.Epigenomics · 2024Review
- The polymer and materials science of the bacterial fimbriae Caf1.Biomaterials science · 2023Review
- Protein folding rate evolution upon mutations.Biophysical reviews · 2023Review
- Proteins' Evolution upon Point Mutations.ACS omega · 2022Article
- Unraveling the molecular determinants of the anti-phagocytic protein cloak of plague bacteria.PLoS pathogens · 2022Article
- Estimating the Influence of Physicochemical and Biochemical Property Indexes on Selection for Amino Acids Usage in Eukaryotic Cells.Journal of molecular evolution · 2021Article
- About the Protein Space Vastness.The protein journal · 2020Review
- Evolutionary Processes and Biophysical Mechanisms: Revisiting Why Evolved Proteins Are Marginally Stable.Journal of molecular evolution · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Here we propose that the upper bound marginal stability of proteins is a universal property that includes macro-molecular complexes and is not affected by molecular changes such as mutations and post-translational modifications. We theorize that its existence is a consequence of Afinsen's thermodynamic hypothesis rather than a result of an evolutionary process. This result enables us to conjecture that neutral evolution should also be, with respect to protein stability, a universal phenomenon.
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Registered trials
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