ArticleSocial cognitive and affective neuroscience2020
Pattern similarity and connectivity of hippocampal-neocortical regions support empathy for pain.
Article in Social cognitive and affective neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Shared effects of the opioid antagonist naltrexone on first-hand and empathic pain.Social cognitive and affective neuroscience · 2026Trial
- Characteristics of pain empathic networks in healthy and primary dysmenorrhea women: an fMRI study.Brain imaging and behavior · 2024Article
- Neuroanatomical markers of social cognition in neglected adolescents.Neurobiology of stress · 2024Article
- Healthcare experience affects pain-specific responses to others' suffering in the anterior insula.Human brain mapping · 2023Article
- Hippocampal integration and separation processes with different temporal and spatial dynamics during learning for associative memory.Human brain mapping · 2023Article
- Entorhinal grid-like codes and time-locked network dynamics track others navigating through space.Nature communications · 2023Article
- Therapeutic touch and therapeutic alliance in pediatric care and neonatology: An active inference framework.Frontiers in pediatrics · 2023Article
- The Neural Representations of Emotional Experiences Are More Similar Than Those of Neutral Experiences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Structural and Functional Asymmetry in Precentral and Postcentral Gyrus in Patients With Unilateral Chronic Shoulder Pain.Frontiers in neurology · 2022Article
- EEG and fMRI evidence for autobiographical memory reactivation in empathy.Human brain mapping · 2021Article
- Dispositional empathy predicts primary somatosensory cortex activity while receiving touch by a hand.Scientific reports · 2021Article
- Synchronous caregiving from birth to adulthood tunes humans' social brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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3 authors.
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Abstract
Empathy is thought to engage mental simulation, which in turn is known to rely on hippocampal-neocortical processing. Here, we tested how hippocampal-neocortical pattern similarity and connectivity contributed to pain empathy. Using this approach, we analyzed a data set of 102 human participants who underwent functional MRI while painful and non-painful electrical stimulation was delivered to themselves or to a confederate. As hypothesized, results revealed increased pattern similarity between first-hand pain and pain empathy (compared to non-painful control conditions) within the hippocampus, retrosplenial cortex, the temporo-parietal junction and anterior insula. While representations in these regions were unaffected by confederate similarity, pattern similarity in the dorsal medial prefrontal cortex was increased the more dissimilar the other individual was perceived. Hippocampal-neocortical connectivity during first-hand pain and pain empathy engaged largely distinct but neighboring primary motor regions, and empathy-related hippocampal coupling with the fusiform gyrus positively scaled with trait measures of perspective taking. These findings suggest that shared representations and mental simulation might contribute to pain empathy via hippocampal-neocortical pattern similarity and connectivity, partially affected by personality traits and the similarity of the observed individual.
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