Evidence map›Paper›PMID 32247816›Full record

ArticlePharmacology, biochemistry, and behavior2020

In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018.

Thomas F Gamage, Daniel G Barrus, Richard C Kevin, David B Finlay, Timothy W Lefever, Purvi R Patel, Megan A Grabenauer, Michelle Glass, Iain S McGregor, Jenny L Wiley and 1 more

Open access · greenAbstract read
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Evaluation of cannabimimetic effects of selected minor cannabinoids and Terpenoids in mice.Progress in neuro-psychopharmacology & biological psychiatry · 2024
    Article
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  7. Structure-activity relationships of valine,RSC medicinal chemistry · 2022
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Thomas F GamageRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Daniel G BarrusRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Richard C KevinThe Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia; Faculty of Science, School of Psychology, The University of Sydney, Sydney, NSW 2006, Australia.
David B FinlayDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Timothy W LefeverRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Purvi R PatelRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Megan A GrabenauerRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Michelle GlassDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Iain S McGregorThe Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia; Faculty of Science, School of Psychology, The University of Sydney, Sydney, NSW 2006, Australia.
Jenny L WileyRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: jwiley@rti.org.
Brian F ThomasRTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
RTI International · USUniversity of Otago · NZUniversity of Sydney · AU

Funding

THC RECEPTORSR01DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 1985 to 2018
$4.9M
Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
THC RECEPTORSR37DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, BILLY R · 1997 to 2006
$2.8M
In vitro and in vivo characterization of CB1 allosteric modulatorsK01DA045752 · NIDA · UPSTATE MEDICAL UNIVERSITY · PI GAMAGE, THOMAS F · 2018 to 2022
$807k
NIDA NIH HHS K01 DA045752NIDA NIH HHS R01 DA003672NIDA NIH HHS R01 DA040460NIDA NIH HHS R37 DA003672
6 · The paper itself

Abstract

Synthetic cannabinoid receptor agonists (SCRAs) possess high abuse liability and complex toxicological profiles, making them serious threats to public health. EG-018 is a SCRA that has been detected in both illicit products and human samples, but it has received little attention to date. The current studies investigated EG-018 at human CB

Indexed as

AnimalsBehavior, AnimalBody TemperatureCannabinoid Receptor AgonistsCarbazolesCyclic AMPDronabinolHEK293 CellsHumansLiverLocomotionMaleMiceMice, Inbred C57BLMice, Inbred ICRMicrosomesCannabinoid Receptor AgonistsCarbazolesCNR1 protein, humanCNR2 protein, humanCyclic AMPDronabinolEG-018NaphthalenesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Synthetic DrugsBehaviorBindingCannabinoidCB(1)CB(2)Novel psychoactive substanceSignaling

Identifiers

PMID32247816
PMCPMC7239729
OpenAlexW3015097529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.