Evidence map›Paper›PMID 32247694›Full record

ArticleGastroenterology2020

Global Burden of 5 Major Types of Gastrointestinal Cancer.

Melina Arnold, Christian C Abnet, Rachel E Neale, Jerome Vignat, Edward L Giovannucci, Katherine A McGlynn, Freddie Bray

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07176052 (Expectation, Pain Outcomes, and Analgesic Efficacy Following Oncology Abdominal Surgery), which is not on this map. Cited by 1,207 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,207citing papers in PubMed, 12 pooled it
76.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07176052 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Expectation, Pain Outcomes, and Analgesic Efficacy Following Oncology Abdominal Surgery: A Cohort Study

Typeobservational_patient_registrySponsorRigshospitalet, DenmarkRan2025 to 2027Enrolled200ConditionsCancer, Hepatic, Cancer, Esophagus, Cancer, PancreasArmscancer surgery
3 · Its place in the literature

Who cites it

1,207 citing papers in PubMed, 12 syntheses or guidelines pooled it, 1,906 citations in OpenAlex.

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1,147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Melina ArnoldSection of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France. Electronic address: arnoldm@iarc.fr.
Christian C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Rachel E NealePopulation Health Division, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Jerome VignatSection of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.
Edward L GiovannucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Katherine A McGlynnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Freddie BraySection of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.
Centre international de recherche sur le cancer · FRNational Cancer Institute · USHarvard University · USQIMR Berghofer Medical Research Institute · AU

Funding

Upper Gastrointestinal Cancer StudiesZIACP000185 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$25.6M
Upper Gastrointestinal Cancer StudiesZ01CP000185 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI DAWSEY, SANFORD M · 2005 to 2008
$1.4M
Intramural NIH HHS Z01 CP000185World Health Organization 001
6 · The paper itself

Abstract

BACKGROUND &

aimsThere were an estimated 4.8 million new cases of gastrointestinal (GI) cancers and 3.4 million related deaths, worldwide, in 2018. GI cancers account for 26% of the global cancer incidence and 35% of all cancer-related deaths. We investigated the global burden from the 5 major GI cancers, as well as geographic and temporal trends in cancer-specific incidence and mortality.

methodsData on primary cancers of the esophagus, stomach, colorectum, liver, and pancreas were extracted from the GLOBOCAN database for the year 2018, as well as from the Cancer Incidence in 5 Continents series, and the World Health Organization mortality database from 1960 onward. Age-standardized incidence and mortality rates were calculated by sex, country, and level of human development.

resultsWe observed geographic and temporal variations in incidence and mortality for all 5 types of GI cancers. Esophageal, gastric, and liver cancers were more common in Asia than in other parts of the world, and the burden from colorectal and pancreatic cancers was highest in Europe and North America. There was a uniform decrease in gastric cancer incidence, but an increasing incidence of colorectal cancer in formerly low-incidence regions during the studied time period. We found slight increases in incidence of liver and pancreatic cancer in some high-income regions.

conclusionsAlthough the incidence of some GI cancer types has decreased, this group of malignancies continues to pose major challenges to public health. Primary and secondary prevention measures are important for controlling these malignancies-most importantly reducing consumption of tobacco and alcohol, obesity control, immunizing populations against hepatitis B virus infection, and screening for colorectal cancer.

Indexed as

AgedAmericasAsiaAustralasiaDatabases, FactualEuropeFemaleGastrointestinal NeoplasmsGeographyGlobal Burden of DiseaseGlobal HealthHealth Services Needs and DemandHumansIncidenceLiver NeoplasmsMaleCancerEpidemiologyGlobalIncidenceMortalityRisk Factors

Identifiers

PMID32247694
PMCPMC8630546
OpenAlexW3014713533

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.